IL-8 (−251 A/T) AND CXCR2 (+1208 C/T) GENE POLYMORPHISMS AND RISK OF MULTIPLE SCLEROSIS IN IRANIAN PATIENTS

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ALIPARASTI M.R.; NIKSERESHT A.R.; KAMALI SARVESTANI E.

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Seminar Paper

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Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Year:2007 | Issue:6

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Title

IL-8 (−251 A/T) AND CXCR2 (+1208 C/T) GENE POLYMORPHISMS AND RISK OF MULTIPLE SCLEROSIS IN IRANIAN PATIENTS

Author(s)

ALIPARASTI M.R. | NIKSERESHT A.R. | KAMALI SARVESTANI E.

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Abstract

Introduction: IL-8 plays important roles in CNS development, modulation of neuronal survival and excitability. Among IL-8 receptors, only CXCR2 is known to be present in the brain. The ability of individuals in producing IL-8 is partially determined by IL-8 −251 A/T polymorphism. Therefore, the aim of the present study was to investigate the association between IL-8 −251 A/T and CXCR2 +1208 C/T gene polymorphisms and susceptibility to multiple sclerosis (MS).Subjects and Methods: Two hundred and twenty-three MS patients and 319 healthy and ethnic matched controls were included in this study. IL-8 promoter (−251 A/T) and CXCR2 (+1208 C/T) gene polymorphisms were genotyped via allele specific PCR (AS-PCR) method.Results & Discussion: A significant difference was found in IL-8−251 A/T polymorphism between MS patients and controls (p=0.04). This deference was a result of a higher incidence of the low producer allele of IL-8 (T allele) in MS patients compared to controls. The results became more significant when the patients and controls were classified (TT) and (AT + AA) genotypes (p=0.02).we suggest that in initial steps of infection, lower ability in recruitment of immune cells to CNS in IL-8 −251 T allele carriers may lead to slower eradication of viral infection which cause increased damage to CNS. However we hypothesized that individuals with IL-8 −251 TT genotype are more susceptible to MS development because they may not be able to repair neuronal damage as efficiently as IL-8 −251 A allele carriers. However, no significant association existed between CXCR2 +1208 C/T polymorphism and MS susceptibility or different clinical parameters in patients.Conclusion: In summary, carriers of IL-8 −251 T allele may have increased susceptibility to MS because of their differences in neuron survival or increased chances of viral persistence compared to carriers of A allele.

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APA: Copy

ALIPARASTI, M.R., NIKSERESHT, A.R., & KAMALI SARVESTANI, E.. (2007). IL-8 (−251 A/T) AND CXCR2 (+1208 C/T) GENE POLYMORPHISMS AND RISK OF MULTIPLE SCLEROSIS IN IRANIAN PATIENTS. BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY. SID. https://sid.ir/paper/902538/en

Vancouver: Copy

ALIPARASTI M.R., NIKSERESHT A.R., KAMALI SARVESTANI E.. IL-8 (−251 A/T) AND CXCR2 (+1208 C/T) GENE POLYMORPHISMS AND RISK OF MULTIPLE SCLEROSIS IN IRANIAN PATIENTS. 2007. Available from: https://sid.ir/paper/902538/en

IEEE: Copy

M.R. ALIPARASTI, A.R. NIKSERESHT, and E. KAMALI SARVESTANI, “IL-8 (−251 A/T) AND CXCR2 (+1208 C/T) GENE POLYMORPHISMS AND RISK OF MULTIPLE SCLEROSIS IN IRANIAN PATIENTS,” presented at the BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY. 2007, [Online]. Available: https://sid.ir/paper/902538/en

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