ASSOCIATION OF CTLA-4 GENE PROMOTER POLYMORPHISMS WITH SYSTEMIC SCLEROSIS IN IRANIAN POPULATION

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ALMASI SH.; ERFANI N.A.; MOJTAHEDI Z.; RAJAEI AKBAR; GHADERI ABAS

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Seminar Paper

Paper Information

Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Year:2007 | Issue:6

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Title

ASSOCIATION OF CTLA-4 GENE PROMOTER POLYMORPHISMS WITH SYSTEMIC SCLEROSIS IN IRANIAN POPULATION

Author(s)

ALMASI SH. | ERFANI N.A. | MOJTAHEDI Z. | RAJAEI AKBAR | GHADERI ABAS

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Abstract

Introduction: In order to explore the role of this immune inhibitory gene in SSc development, in the present study, the polymorphisms in the CTLA-4 promoter region (-1722 T/C, -1661 A/G and -318 C/T) were investigated.Subjects and Methods: -1722 T/C, -1661 A/G and -318 C/T polymorphisms were genotyped using Polymerase Chain Reaction with Confronting Two-Pair Primers(PCR-CTPP), Restriction Fragment Length Polymorphism (PCR-RFLP) and Amplification Refractory Mutation System (PCR-ARMS) methods, respectively, in 83 SSc patients and 166 healthy controls.Results: All genotypes and allele frequencies in patients were significantly different from the control group (P=0.022 for -1722 T/C, P=0.03 for -1661 A/G and P=0.014 for -318 C/T genotypes). The -1722C, -1661G and -318T alleles contributed to SSc with P=0.012, odds ratio (OR) 2.16, P=0.031, OR 1.82 and P=0.023, OR 2.45, respectively. A significant difference was observed in the frequency homozygous ‘genotype combination’ -1722TT/ -1661AA/-318CC of these three polymorphisms (Pc=0.003). The frequency of this genotype combination was significantly higher in the control group than in patients.Discussion: Statistical analyses indicate increased heterozygous genotypes and mutant alleles in SSc patients, from one side, and increased wild-type homozygous genotypes and wild type alleles in controls subjects, from the other side. In addition, the wild-type homozygous ‘genotype combination’ of these three loci occurred more frequently in the control group than in SSc patients (Pc=0.003).Conclusion: Results of this investigation indicate that -1722C, -1661G and -318T alleles of CTLA-4 gene promoter appear to be associated with SSc, and individuals carrying these alleles may be more susceptible to this disease.

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APA: Copy

ALMASI, SH., ERFANI, N.A., MOJTAHEDI, Z., RAJAEI, AKBAR, & GHADERI, ABAS. (2007). ASSOCIATION OF CTLA-4 GENE PROMOTER POLYMORPHISMS WITH SYSTEMIC SCLEROSIS IN IRANIAN POPULATION. BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY. SID. https://sid.ir/paper/902540/en

Vancouver: Copy

ALMASI SH., ERFANI N.A., MOJTAHEDI Z., RAJAEI AKBAR, GHADERI ABAS. ASSOCIATION OF CTLA-4 GENE PROMOTER POLYMORPHISMS WITH SYSTEMIC SCLEROSIS IN IRANIAN POPULATION. 2007. Available from: https://sid.ir/paper/902540/en

IEEE: Copy

SH. ALMASI, N.A. ERFANI, Z. MOJTAHEDI, AKBAR RAJAEI, and ABAS GHADERI, “ASSOCIATION OF CTLA-4 GENE PROMOTER POLYMORPHISMS WITH SYSTEMIC SCLEROSIS IN IRANIAN POPULATION,” presented at the BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY. 2007, [Online]. Available: https://sid.ir/paper/902540/en

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