THE EVALUATION OF HEPATITIS C VIRUS ANTIBODIES IN A FEW SKIN AUTOIMMUNE DISORDERS

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JADALI Z.; MANSOURI P.

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Seminar Paper

Paper Information

Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Year:2007 | Issue:6

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Title

THE EVALUATION OF HEPATITIS C VIRUS ANTIBODIES IN A FEW SKIN AUTOIMMUNE DISORDERS

Author(s)

JADALI Z. | MANSOURI P.

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Abstract

Hepatitis C virus (HCV) infection has been associated with a plethora of immune and autoimmune perturbations. A variety of conditions ranging from endocrinopathies to different skin autoimmune disorders with HCV infection has been reported in the literature. Some data accessible so far are controversial. The aim of this study was to investigate the prevalence and clinical significance of HCV infection in a few skin autoimmune diseases known to be related with HCV infection including vitiligo, alopecia areata and psoriasis.Serum samples from 150 patients with a variety of skin autoimmune diseases (65 with vitiligo, 45 with alopecia areata and 40 with psoriasis) were studied and compared with normal controls. Third generation ELISA test was used for detection of antibodies to HCV in human sera and anti-HCV seropositivity was confirmed by recombinant immunoblot assay (RIBA).All patients with alopecia areata, psoriasis and normal controls were anti-HCV negative, whereas anti-HCV antibody was present in 1 patient with vitiligo confirmed by Western blotting. Fisher’s exact test was used to compare relative frequencies. These results indicate that there was no significant difference of anti-HCV antibodies between patients and controls.In this study no relationship was found between vitiligo, alopecia areata and psoriasis with HCV infection, which implies that hepatitis C virus does not play a direct causal role in the pathogenesis of these autoimmune disorders; however, this does not rule out a ‘hit and run’ virus induced diseases.

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APA: Copy

JADALI, Z., & MANSOURI, P.. (2007). THE EVALUATION OF HEPATITIS C VIRUS ANTIBODIES IN A FEW SKIN AUTOIMMUNE DISORDERS. BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY. SID. https://sid.ir/paper/902556/en

Vancouver: Copy

JADALI Z., MANSOURI P.. THE EVALUATION OF HEPATITIS C VIRUS ANTIBODIES IN A FEW SKIN AUTOIMMUNE DISORDERS. 2007. Available from: https://sid.ir/paper/902556/en

IEEE: Copy

Z. JADALI, and P. MANSOURI, “THE EVALUATION OF HEPATITIS C VIRUS ANTIBODIES IN A FEW SKIN AUTOIMMUNE DISORDERS,” presented at the BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY. 2007, [Online]. Available: https://sid.ir/paper/902556/en

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