CORRELATION BETWEEN ALPHA1-ANTITRYPSIN PHENOTYPES (AAT) AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

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NAJAVAND S.; LOTFI A.S.; MESBAH S.A.; MOTA A.; KHOUSH DEL A.; ETEMADIKIA B.

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Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Year:2007 | Issue:6

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Title

CORRELATION BETWEEN ALPHA1-ANTITRYPSIN PHENOTYPES (AAT) AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Author(s)

Keywords

ALPHA1-ANTITRYPSIN

ISO ELECTROPHORESE FOCUSING

PLEIOMORPHISM

Abstract

COPD is characterised by a slowly progressive irreversible airflow obstruction which is due to peripheral airway inflammation and loss of lung elastic recoil resulting from parenchymal destruction. Cigarette smoking is the major risk factor for COPD. Genes, including those for ALPHA1-ANTITRYPSIN (AAT), a1-anti chymotrypsin (AACT), a2-macroglobulin etc, have also been associated with the development of COPD. AAT is a highly pleiomorphic protein, thus reflecting a pleiomorphic gene locus, with roughly 100 alleles having been identified to date. The most common variant, M, characterized by normal serum AAT levels. The Z and S variants are associated with AAT deficiency. Individuals with the ZZ genotypes have severe AAT deficiency, and are at increased risk for COPD. This research is conducted with the aim of identification and report of AAT variants in COPD patients. Study subjects were 76 Patients (62 male and 14 female) with COPD who were selected from lung disease center and their reports including personal characteristics (age, sex, etc), illness family history, clinical symptoms, were closely examined. ISO ELECTROPHORESE FOCUSING technique was used to identify AAT phenotypes. 76 control subjects who were similar with respect to age, race, habit smoking and sex. Statistical analyseswere performed with SPSS. The associations of the Z and S mutations with COPD were tested by the fisher's exact test. The prevalence of MS heterozygosity in all of the study subjects was 2 of 76 (2.6%) compared with 1 of 76 (1.3%) control subjects. Six of 76 (7.9%) of subjects in the study were heterozygous for the Z alleles (MZ), compared with 0 of 76 (0%) control subjects. One ZZ individual (1.3%) was detected, whereas no individual with SS or SZ phenotypes were found. The prevalence of MZ heterozygotes in study subjects was increased (P=0.028) compared with control subjects after correction for age, gender, and smoking history. The results also, demonstrated no difference (P=1.000) in the prevalence of MS heterozygotes in the study group compared with the control group. Probably, these results’ indicating the Z, but not the S, allele is a risk factor for COPD in the heterozygous state and may reflect the fact that the S allele is a mild deficiency variant and if an increased risk of COPD is associated with the S allele, it would be expected to be small. The percentage of the predicted FEV1 was reduced in MZ compared with MM individuals among those with clinically established COPD.

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APA: Copy

NAJAVAND, S., LOTFI, A.S., MESBAH, S.A., MOTA, A., KHOUSH DEL, A., & ETEMADIKIA, B.. (2007). CORRELATION BETWEEN ALPHA1-ANTITRYPSIN PHENOTYPES (AAT) AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD). BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY. SID. https://sid.ir/paper/902571/en

Vancouver: Copy

NAJAVAND S., LOTFI A.S., MESBAH S.A., MOTA A., KHOUSH DEL A., ETEMADIKIA B.. CORRELATION BETWEEN ALPHA1-ANTITRYPSIN PHENOTYPES (AAT) AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD). 2007. Available from: https://sid.ir/paper/902571/en

IEEE: Copy

S. NAJAVAND, A.S. LOTFI, S.A. MESBAH, A. MOTA, A. KHOUSH DEL, and B. ETEMADIKIA, “CORRELATION BETWEEN ALPHA1-ANTITRYPSIN PHENOTYPES (AAT) AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD),” presented at the BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY. 2007, [Online]. Available: https://sid.ir/paper/902571/en

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