NEUROPEPTIDES: CONTROL OF HORMONE SECRETION, APPETITE, AROUSAL AND PAIN

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TAKAHASHI K.

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2007 | Issue:18

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Title

NEUROPEPTIDES: CONTROL OF HORMONE SECRETION, APPETITE, AROUSAL AND PAIN

Author(s)

TAKAHASHI K.

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Abstract

Neuropeptides include a broad rage of peptides with various biological functions. For example, hypothalamic hormones, such as corticotropin releasing hormone (CRH) and gonadotropin-releasing hormone (GnRH), regulate the secretion of anterior pituitary hormones. In addition, certain neuropeptides in the hypothalamus regulate the appetite. Neuropeptides Y (NPY), melanin-concentrating hormone (MCH), and orexin-A stimulate appetite, whereas a-melanocyte stimulating hormone (aMSH) and CRH suppress the appetite. Actually, one neuropeptide plays multiple roles in the brain, and interacts with classical neurotransmitters, such as catecholamines and histamine. For example, orexin-A stimulates the arousal and interacts with histamine. The dysfunction in the orexin-A function results in a sleep disorder, narcolepsy. Furthermore, central administration of orexins enhanced anti-nociception in mice. This anti-nociceptive effect was further enhanced in histamine H1 or H2 receptor gene knockout mice. Therefore, orexin-A is related not only to the appetite control, but also to the arousal and pain control, possibly via the interaction with histamine. I would like to summarize the research in neuropeptides focusing on their multiple functions in the brain.

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APA: Copy

TAKAHASHI, K.. (2007). NEUROPEPTIDES: CONTROL OF HORMONE SECRETION, APPETITE, AROUSAL AND PAIN. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/903047/en

Vancouver: Copy

TAKAHASHI K.. NEUROPEPTIDES: CONTROL OF HORMONE SECRETION, APPETITE, AROUSAL AND PAIN. 2007. Available from: https://sid.ir/paper/903047/en

IEEE: Copy

K. TAKAHASHI, “NEUROPEPTIDES: CONTROL OF HORMONE SECRETION, APPETITE, AROUSAL AND PAIN,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2007, [Online]. Available: https://sid.ir/paper/903047/en

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