ENDOGENOUS LTP IMPAIRS LTP INDUCTION IN HIPPOCAMPAL DENTATE GYRUS OF MORPHINE DEPENDENT ANESTHETIZED RATS

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SAFARI M.SH.; MOTAMEDI F.

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Seminar Paper

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Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2007 | Issue:18

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Title

ENDOGENOUS LTP IMPAIRS LTP INDUCTION IN HIPPOCAMPAL DENTATE GYRUS OF MORPHINE DEPENDENT ANESTHETIZED RATS

Author(s)

SAFARI M.SH. | MOTAMEDI F.

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Abstract

There are different controversial results about the effect of morphine dependency on electrophysiological properties of hippocampal field potentials and induction and maintenance of long term potentiation (LTP). In this study the effect of chronic morphine treatment on hippocampal dentate gyrus baseline synaptic activity and long-term potentiation (LTP) was examined in vivo. The field excitatory postsynaptic potential (fEPSP) and population spikes (PS) was recorded from dentate gyrus following stimulation of perforant path in control and morphine-dependent anesthetized rats. Addiction protocol was 20 days subcutaneous injection of morphine (10 mg/kg) twice daily at 12 hours interval. To induce LTP, a 100-Hz high frequency stimulation (HFS) protocol was used. Input-Output (I/O) curve plotting showed: 1) Morphine dependency potentiates baseline fEPSP slope in lower stimulation intensities which is reversed by Naloxone administration in anesthetized rats. 2) In contrast Morphine dependency has no effect on the baseline PS amplitude. LTP induction protocol showed: 1) with tetanic stimulation fEPSP-LTP induction impairs and approaching to normal level by Naloxone administration 5 min before or after HFS. 2) Morphine dependency has no significant effect on PS-LTP induction. These findings suggest that hippocampal dentate gyrus fEPSP-LTP is impaired in morphine dependent rats and can still be achieved in morphine withdrawal period by naloxone through mechanisms that may be inhibited by opiate exposure. The basal synaptic efficacy was potentiated in morphine dependency suggests that morphine dependency might cause an endogenous LTP, which influence the subsequent induction of LTP in dentate gyrus.

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APA: Copy

SAFARI, M.SH., & MOTAMEDI, F.. (2007). ENDOGENOUS LTP IMPAIRS LTP INDUCTION IN HIPPOCAMPAL DENTATE GYRUS OF MORPHINE DEPENDENT ANESTHETIZED RATS. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/903481/en

Vancouver: Copy

SAFARI M.SH., MOTAMEDI F.. ENDOGENOUS LTP IMPAIRS LTP INDUCTION IN HIPPOCAMPAL DENTATE GYRUS OF MORPHINE DEPENDENT ANESTHETIZED RATS. 2007. Available from: https://sid.ir/paper/903481/en

IEEE: Copy

M.SH. SAFARI, and F. MOTAMEDI, “ENDOGENOUS LTP IMPAIRS LTP INDUCTION IN HIPPOCAMPAL DENTATE GYRUS OF MORPHINE DEPENDENT ANESTHETIZED RATS,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2007, [Online]. Available: https://sid.ir/paper/903481/en

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