EFFECT OF CO-ADMINISTRATION OF GARLIC AND CHLORPROPAMIDE ON BLOOD GLUCOSE IN DIABETIC RATS

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KARAMI BONARI A.R.

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2009 | Issue:19

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Title

EFFECT OF CO-ADMINISTRATION OF GARLIC AND CHLORPROPAMIDE ON BLOOD GLUCOSE IN DIABETIC RATS

Author(s)

KARAMI BONARI A.R.

Keywords

DIABETES MELLITUS

GARLIC

CHLORPROPAMIDE

RAT

Abstract

DIABETES MELLITUS is a common endocrine disorder characterized by hyperglycemia. Polytherapy is said to be a current pharmacological principle having the advantage of producing maximum therapeutic efficacy with minimum side effects. GARLIC is one of the most popular herbs used worldwide to reduce various risk factors associated with diseases. We assessed the antidiabetic efficacy by a combination of GARLIC and CHLORPROPAMIDE. Fifty Wistar RATs, 10 non-diabetic and 40 induced-diabetic RATs by alloxan (150mg/kg b.w, i.p), were used. The diabetic RATs were divided equally into 4 groups: group 1: treated with saline (2ml/kg p.o, diabetic control), group 2: treated with CHLORPROPAMIDE (250mg/kg p.o.), group 3: treated with GARLIC (0.5g/kg p.o.) and group 4: treated with CHLORPROPAMIDE and GARLIC. All drugs were given for 24 days. CHLORPROPAMIDE and GARLIC and their combination produced significant (P<0.05) reductions in blood glucose concentrations of diabetic (hyperglycemic) RATs. The maximum reduction occurred in group 4. In the group treated with combined CHLORPROPAMIDE and GARLIC, effects were synergistic, hence more beneficial than individual treatments.

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APA: Copy

KARAMI BONARI, A.R.. (2009). EFFECT OF CO-ADMINISTRATION OF GARLIC AND CHLORPROPAMIDE ON BLOOD GLUCOSE IN DIABETIC RATS. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/904126/en

Vancouver: Copy

KARAMI BONARI A.R.. EFFECT OF CO-ADMINISTRATION OF GARLIC AND CHLORPROPAMIDE ON BLOOD GLUCOSE IN DIABETIC RATS. 2009. Available from: https://sid.ir/paper/904126/en

IEEE: Copy

A.R. KARAMI BONARI, “EFFECT OF CO-ADMINISTRATION OF GARLIC AND CHLORPROPAMIDE ON BLOOD GLUCOSE IN DIABETIC RATS,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2009, [Online]. Available: https://sid.ir/paper/904126/en

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