HISTOPATHOLOGIC STUDY ON NEPHROTOXICITY OF FLUNIXIN-MEGLUMIN IN RAT

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DERAKHSHANFAR A.

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Seminar Paper

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Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2007 | Issue:18

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Title

HISTOPATHOLOGIC STUDY ON NEPHROTOXICITY OF FLUNIXIN-MEGLUMIN IN RAT

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DERAKHSHANFAR A.

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Abstract

Introduction: flunixin - meglumin (FM) is one of the non steroidal anti inflammatory drugs with antipyretic and analgesic effects. FM uses mainly in veterinary medicine in treatment of inflammation and colic of horses.Methods: in this study, 28 rats were divided into 4 equal groups randomly. Group1, 2 and 3 received 2.5, 3.5 and 5 mg/ kg of FM for 5 days (IM), respectively. Group 1 received therapeutic dose of the drug. Group 4 as control received normal saline. At the end of experiment all of the rats were euthanized and their kidneys sent to laboratory for preparing the tissue slides.Results: clinical observation revealed weight loss, anorexia and diarrhea. Rats in groups 1, 2 died in day 5 and rats in group 3 died in day 3. Histopathologic examination showed acute tubular coagulation necrosis and thickening of the capsule in groups 1, 2 and 3 and renal infarction and medullary necrosis in group 3. Rats in group 4 were normal.Conclusion: it seems that FM inhibits prostaglandin and its utility must be with caution.

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APA: Copy

DERAKHSHANFAR, A.. (2007). HISTOPATHOLOGIC STUDY ON NEPHROTOXICITY OF FLUNIXIN-MEGLUMIN IN RAT. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/904602/en

Vancouver: Copy

DERAKHSHANFAR A.. HISTOPATHOLOGIC STUDY ON NEPHROTOXICITY OF FLUNIXIN-MEGLUMIN IN RAT. 2007. Available from: https://sid.ir/paper/904602/en

IEEE: Copy

A. DERAKHSHANFAR, “HISTOPATHOLOGIC STUDY ON NEPHROTOXICITY OF FLUNIXIN-MEGLUMIN IN RAT,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2007, [Online]. Available: https://sid.ir/paper/904602/en

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