EVALUATION OF HISTAMINERGIC EFFECTS ON ANXIETY-RELATED BEHAVIORS IN LATERAL SEPTUM, USING EPM TEST IN WISTAR MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VALIZADEGAN F.; ROSTAMI P.; ZARINDAST M.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2007 | Issue:18

Download Full-Text

View:

129

Download:

Information Seminar Paper

Title

EVALUATION OF HISTAMINERGIC EFFECTS ON ANXIETY-RELATED BEHAVIORS IN LATERAL SEPTUM, USING EPM TEST IN WISTAR MALE RATS

Author(s)

VALIZADEGAN F. | ROSTAMI P. | ZARINDAST M.R.

Keywords

Not Registered.

Abstract

Introduction: It has been suggested that histamine have modulatory influence on anxiety-related behaviors both in human and animals. lateral septum (LS) may also be an important brain site in modulation of fear and anxiety.Methods: In the present study, the effects of histaminergic agents on anxiety-related behaviors in the rats, using elevated-plus maze test has been investigated, and anxiety parameters such as open arm time (OAT), open arm entries (OAE) and locomotor activity (LOC) have been avaluated.Results: Intra-LS administration of histamine (0.1, 0.5, 1μg/rat), decreased %OAE and %OAT but not locomotor activity. Showing an anxiogenic response. Intra-LS microinjections of pyrilamine (a H1 receptor antagonist) or ranitidine (a H2 receptor antagonist) (5, 10, 20μg/rat) alone had no effect on mentioned parameters. Pretreatment of animals with either pyrilamine or ranitidine in mentioned doses, revers anxiogenic response of histamine (1 μg/rat).Conclusion: Our results showed that histamine may modulate anxiety-like behaviors via H1 and H2 receptors in the lateral septum on the rats.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

VALIZADEGAN, F., ROSTAMI, P., & ZARINDAST, M.R.. (2007). EVALUATION OF HISTAMINERGIC EFFECTS ON ANXIETY-RELATED BEHAVIORS IN LATERAL SEPTUM, USING EPM TEST IN WISTAR MALE RATS. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/904956/en

Vancouver: Copy

VALIZADEGAN F., ROSTAMI P., ZARINDAST M.R.. EVALUATION OF HISTAMINERGIC EFFECTS ON ANXIETY-RELATED BEHAVIORS IN LATERAL SEPTUM, USING EPM TEST IN WISTAR MALE RATS. 2007. Available from: https://sid.ir/paper/904956/en

IEEE: Copy

F. VALIZADEGAN, P. ROSTAMI, and M.R. ZARINDAST, “EVALUATION OF HISTAMINERGIC EFFECTS ON ANXIETY-RELATED BEHAVIORS IN LATERAL SEPTUM, USING EPM TEST IN WISTAR MALE RATS,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2007, [Online]. Available: https://sid.ir/paper/904956/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops