EFFECT OF MORPHINE-DEPENDENT ON SPATIAL MEMORY IN RATS

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MILADI GORJI H.; RASHIDIPOUR A.; FATH ELAHI Y.; VAFAEI A.A.; TEHRANI A.A.

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Seminar Paper

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Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2007 | Issue:18

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Title

EFFECT OF MORPHINE-DEPENDENT ON SPATIAL MEMORY IN RATS

Author(s)

MILADI GORJI H. | RASHIDIPOUR A. | FATH ELAHI Y. | VAFAEI A.A. | TEHRANI A.A.

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Abstract

Introduction: Numerous studies have dealt with the role of opiate system in tasks aimed at measurement of cognitive behavior, but the role of morphine dependency on learning and memory (long and short term) is still controversial. Thus, in this study chronic exposure to morphine was employed to evaluate learning ability and spatial short term and long term memories in the Morris water maze task.Methods: Twenty male albino rats (250-300gr) were made dependent by chronic administration of morphine in drinking water that lasted at least 21 days. Control groups received only sucrose in their water. In experiment 1, Rats were submitted 6 trials a sessions for 6 consecutive days to find the submerged platform that was located in the center of a quadrant of the tank. The rat was allowed 60 s to search for the platform, then latency to find the platform. Performance was tested 24hr after the last training session in a probe trial (60 s) in which there was no platform present and the time spent in the quadrant of the former platform position was taken as measures for spatial memory. In experiment 2, two days after termination of the reference memory testing, training on the working memory version of the navigation task was started. Only two trials per day were given until performance stabilized (at least 5 days). Final test was done at day 6.Results: In Expt.1, we observed that all animals learned to locate the platform during the 6 successive days of training. In Probe test, results indicated that morphine dependent group spent significantly less time in the target quadrant in comparison to control group. No significant differences were found on acquisition and retention trials between morphine and control groups.Conclusion: Our findings indicate that chronic exposure to morphine impairs spatial long-term memory, but has no effect on spatial short-term memory.

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APA: Copy

MILADI GORJI, H., RASHIDIPOUR, A., FATH ELAHI, Y., VAFAEI, A.A., & TEHRANI, A.A.. (2007). EFFECT OF MORPHINE-DEPENDENT ON SPATIAL MEMORY IN RATS. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/905009/en

Vancouver: Copy

MILADI GORJI H., RASHIDIPOUR A., FATH ELAHI Y., VAFAEI A.A., TEHRANI A.A.. EFFECT OF MORPHINE-DEPENDENT ON SPATIAL MEMORY IN RATS. 2007. Available from: https://sid.ir/paper/905009/en

IEEE: Copy

H. MILADI GORJI, A. RASHIDIPOUR, Y. FATH ELAHI, A.A. VAFAEI, and A.A. TEHRANI, “EFFECT OF MORPHINE-DEPENDENT ON SPATIAL MEMORY IN RATS,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2007, [Online]. Available: https://sid.ir/paper/905009/en

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