C-REACTIVE PROTEIN AS A MARKER OF SYSTEMIC INFLAMMATION: IMPLICATION OF STATIN AND ANTI- INFLAMMATORY THERTAPY IN THE PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE

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YURI GASPARYAN ARMEN

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Seminar Paper

Paper Information

Seminar: INTERNATIONAL CONGRESS OF METABOLIC SYNDROME, OBESITY & DIABETES
Year:2010 | Issue:2

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Title

C-REACTIVE PROTEIN AS A MARKER OF SYSTEMIC INFLAMMATION: IMPLICATION OF STATIN AND ANTI- INFLAMMATORY THERTAPY IN THE PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE

Author(s)

YURI GASPARYAN ARMEN

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Abstract

C-REACTIVE PROTEIN (CRP) PLAYS A CRUCIAL ROLE AT ALL STAGES OF ATHEROGENESIS. IT DEMONSTRATES IMMUNE MODULATING EFFECTS AND WAS FOUND IN THE ATHEROSCLEROTIC PLAQUE, FACILITATING ITS DESTABILIZATION AND RUPTURE. IN SOME CHRONIC INFLAMMATORY DISORDERS THIS INFLAMMATORY AGENT IS RECOGNIZED AS A SPECIFIC MARKER OF ACTIVITY. THE CLASSIC EXAMPLE, IN THIS REGARD, IS RHEUMATOID ARTHRITIS, WHERE SUPPRESSION OF CRP PRODUCTION IN THE RETICULOENDOTHELIAL SYSTEM BY STATINS AND DISEASE-MODIFYING ANTI-RHEUMATIC DRUGS SUCH AS METHOTREXATE IS ASSOCIATED WITH AMELIORATION OF THE DISEASE COURSE AND PREVENTION OF CARDIOVASCULAR MORBIDITY AND MORTALITY. OVER THE PAST YEARS, IT HAS BECOME CLEAR THAT CRP IS A MARKER OF SYSTEMIC INFLAMMATION WITH A STRONG PREDICTIVE CARDIOVASCULAR VALUE. IN FACT, THE PHYSICIANS' HEALTH STUDY (PHS) AND THE JUSTIFICATION FOR THE USE OF STATINS IN PREVENTION-AN INTERVENTION TRIAL EVALUATING ROSUVASTATIN (JUPITER) PROVED THAT CRP CAN PREDICT OCCURRENCE OF CARDIOVASCULAR EVENTS IN APPARENTLY HEALTHY SUBJECTS AND INDICATED THE NEED TO MODIFY AVAILABLE GUIDELINES FOR PRIMARY PREVENTION. BASED ON THESE LANDMARK TRIALS, IT IS NOW CLEAR THAT ASPIRIN AND STATINS EXERT THEIR CARDIO PROTECTIVE EFFECT VIA SUPPRESSION OF LOW-GRADE INFLAMMATION IN SUBJECTS BURDENED WITH CARDIOVASCULAR RISK FACTORS. THE SEARCH FOR OTHER DRUGS WITH CARDIO PROTECTIVE AND ANTI-INFLAMMATORY EFFECTS IS UNDERWAY AND IT IS HOPED THAT METHOTREXATE AND COLCHICINES WILL BE INCLUDED IN THE ARMAMENTARIUM OF PREVENTIVE MEASURE FOR SUBJECTS AT HIGH RISK CARDIOVASCULAR EVENTS AND THOSE UNDERGOING CONORARY INTERVENTIONS.

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APA: Copy

YURI GASPARYAN, ARMEN. (2010). C-REACTIVE PROTEIN AS A MARKER OF SYSTEMIC INFLAMMATION: IMPLICATION OF STATIN AND ANTI- INFLAMMATORY THERTAPY IN THE PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE. INTERNATIONAL CONGRESS OF METABOLIC SYNDROME, OBESITY & DIABETES. SID. https://sid.ir/paper/905197/en

Vancouver: Copy

YURI GASPARYAN ARMEN. C-REACTIVE PROTEIN AS A MARKER OF SYSTEMIC INFLAMMATION: IMPLICATION OF STATIN AND ANTI- INFLAMMATORY THERTAPY IN THE PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE. 2010. Available from: https://sid.ir/paper/905197/en

IEEE: Copy

ARMEN YURI GASPARYAN, “C-REACTIVE PROTEIN AS A MARKER OF SYSTEMIC INFLAMMATION: IMPLICATION OF STATIN AND ANTI- INFLAMMATORY THERTAPY IN THE PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE,” presented at the INTERNATIONAL CONGRESS OF METABOLIC SYNDROME, OBESITY & DIABETES. 2010, [Online]. Available: https://sid.ir/paper/905197/en

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