A GREEN METHOD BASE ON DISPERSIVE LIQUID-LIQUID MICROEXTRACTION FOR PRECONCENTRATION AND DETERMINATION OF CHLORPROPAMIDE

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AIBAGHI ESFAHANI B.; Rameh F.; Ghoraba Z.

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Seminar Paper

Paper Information

Seminar: SEMINAR OF CHEMISTRY AND ENVIRONMENT
Year:2015 | Issue:7

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Title

A GREEN METHOD BASE ON DISPERSIVE LIQUID-LIQUID MICROEXTRACTION FOR PRECONCENTRATION AND DETERMINATION OF CHLORPROPAMIDE

Author(s)

AIBAGHI ESFAHANI B. | Rameh F. | Ghoraba Z. | Issue Writer Certificate

Keywords

DISPERSIVE LIQUID LIQUID MICROEXTRACTION

CHLORPROPAMIDE

GREEN CHEMISTRY

PRECONCENTRATION

HPLC

Abstract

CHLORPROPAMIDE IS ONE OF SULPHONYLUREA DERIVATIVES THAT ARE WIDELY USED AS AN ORAL HYPOGLYCEMIC DRUG FOR THE TREATMENT OF NON-INSULIN-DEPENDENT DIABETES MELLITUS. AN EXCESS DOSE OF CHLORPROPAMIDE CAN CAUSE SIDE EFFECTS INCLUDING HYPOGLYCEMIC SYMPTOMS AND COMA, BECAUSE IT POSSIBLY STIMULATES EXCESSIVE INSULIN PRODUCTION. THEREFORE, MONITORING THERAPEUTIC BLOOD LEVELS IS REQUIRED FOR THE MANAGEMENT OF SIDE EFFECTS OF CHLORPROPAMIDE1. DISPERSIVE LIQUIDLIQUID MICROEXTRACTION IS A MINIATURIZED SAMPLE PREPARATION PROCEDURE INSIDE GREEN CHEMISTRY BECAUSE THE LOW VOLUME OF SOLVENT EMPLOYED2. THIS TECHNIQUE COUPLED WITH HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-UV DETECTOR (HPLC-UV) TO DETERMINATION OF CHLORPROPAMIDE3. IN THIS EXTRACTION METHOD, DICHLOROMETHANE WAS USED AS AN EXTRACTION SOLVENT. HPLC SYSTEM INCLUDE A MZ-ANALYSENTECHNIK C18, 250×4.6 MM COLUMN AND THE MOBILE PHASE METHANOL: 0.2% ACETIC ACID IN THE RATIO OF (3: 2) WITH A UV DETECTOR (L=232 NM) WAS USED. IN THIS METHOD THE EFFECT OF PH, TYPE AND VOLUME OF BUFFER, TYPE AND VOLUME OF EXTRACTION SOLVENT, EXTRACTION TIME AND EFFECT OF INTERFERING IONS WERE INVESTIGATED. UNDER THE OPTIMAL CONDITIONS, LINEARITY RANGE WAS OBTAINED FROM 1-100 NG/ML (R=0.999), DETECTION LIMIT WAS 0.2 NG/ML OF CHLORPROPAMIDE.THE METHOD WAS SUCCESSFULLY APPLIED TO DETERMINATION OF CHLORPROPAMIDE IN HUMAN PLASMA AND PHARMACEUTICAL SAMPLES.

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APA: Copy

AIBAGHI ESFAHANI, B., Rameh, F., & Ghoraba, Z.. (2015). A GREEN METHOD BASE ON DISPERSIVE LIQUID-LIQUID MICROEXTRACTION FOR PRECONCENTRATION AND DETERMINATION OF CHLORPROPAMIDE. SEMINAR OF CHEMISTRY AND ENVIRONMENT. SID. https://sid.ir/paper/911980/en

Vancouver: Copy

AIBAGHI ESFAHANI B., Rameh F., Ghoraba Z.. A GREEN METHOD BASE ON DISPERSIVE LIQUID-LIQUID MICROEXTRACTION FOR PRECONCENTRATION AND DETERMINATION OF CHLORPROPAMIDE. 2015. Available from: https://sid.ir/paper/911980/en

IEEE: Copy

B. AIBAGHI ESFAHANI, F. Rameh, and Z. Ghoraba, “A GREEN METHOD BASE ON DISPERSIVE LIQUID-LIQUID MICROEXTRACTION FOR PRECONCENTRATION AND DETERMINATION OF CHLORPROPAMIDE,” presented at the SEMINAR OF CHEMISTRY AND ENVIRONMENT. 2015, [Online]. Available: https://sid.ir/paper/911980/en

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