EFFECT OF BIOLOGICAL LIGANDS IN COPPER INTOXICATION

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KAVIRIZADEH R.; AMIRI A.; SHAHSAVARI M.

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Seminar Paper

Paper Information

Seminar: SEMINAR OF CHEMISTRY AND ENVIRONMENT
Year:2015 | Issue:7

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Title

EFFECT OF BIOLOGICAL LIGANDS IN COPPER INTOXICATION

Author(s)

KAVIRIZADEH R. | AMIRI A. | SHAHSAVARI M. | Issue Writer Certificate

Keywords

CHELATION THERAPY

DEFERASIROX

DEFERIPRONE

COPPER TOXICITY

RATS

Abstract

THE HYPOTHESIS THAT TWO KNOWN CHELATORS DEFERIPRONE (L1) AND DEFERASIROX (DFS) MIGHT BE MORE EFFICIENT AS COMBINED TREATMENT THAN AS MONOTHERAPIESIN MOBILIZATION OF COPPER WAS TESTEDIN COPPER-EXPOSED RATS [1, 2]. MALE WISTAR RATS WERE EXPOSED TO 70 MG/KG BODY WEIGHT COPPER (II) CHLORIDE IN DRINKING WATER FOR 42 DAYS, FOLLOWED BY TREATMENT WITH DFS, L1 EITHER ALONE OR IN COMBINATION DFS+L1, FOR 10 CONSECUTIVE DAYS. AFTER CHELATION THERAPY, THESE RATS WERE ANESTHETIZED WITH ETHER VAPOR AND IMMOBILIZED BY CERVICAL DISLOCATION AND THEN THEIR HEART, LIVER, KIDNEYS AND INTESTINE WERE SAMPLED FOR DETERMINATION OF COPPER, IRON AND CONCENTRATION WITH AN ATOMIC ABSORPTION SPECTROPHOTOMETER. THE TREATMENT WITH DFS AND L1 APPRECIABLY DECREASED THE DEPLETION OF ENDOGENOUS COPPER BUT THE COMBINED TREATMENTS WERE MORE EFFICIENT THAN THE INDIVIDUALS IN RESTORING THE TISSUE COPPER LEVELS. FURTHERMORE, IRON AND ZINC CONCENTRATION AFTER CHELATION THERAPY SIGNIFICANTLY DECREASED, THUS CONSUMPTION OF IRON AND ZINC TABLET IS RECOMMENDED TO RETURN IRON AND ZINC LEVEL TO ITS NORMAL STATE. OUR RESULTS SUPPORT THE USEFULNESS OF THIS ANIMAL MODEL FOR PRELIMINARY IN VIVO TESTING OF COPPER CHELATORS. RESULT OF COMBINED CHELATORS TREATMENT SHOULD BE CONFIRMED IN A DIFFERENT EXPERIMENTAL MODEL BEFORE EXTRAPOLATION TO OTHER SYSTEMS.

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APA: Copy

KAVIRIZADEH, R., AMIRI, A., & SHAHSAVARI, M.. (2015). EFFECT OF BIOLOGICAL LIGANDS IN COPPER INTOXICATION. SEMINAR OF CHEMISTRY AND ENVIRONMENT. SID. https://sid.ir/paper/912049/en

Vancouver: Copy

KAVIRIZADEH R., AMIRI A., SHAHSAVARI M.. EFFECT OF BIOLOGICAL LIGANDS IN COPPER INTOXICATION. 2015. Available from: https://sid.ir/paper/912049/en

IEEE: Copy

R. KAVIRIZADEH, A. AMIRI, and M. SHAHSAVARI, “EFFECT OF BIOLOGICAL LIGANDS IN COPPER INTOXICATION,” presented at the SEMINAR OF CHEMISTRY AND ENVIRONMENT. 2015, [Online]. Available: https://sid.ir/paper/912049/en

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