BINDING CONSTANTS FOR INDIUM (III) WITH HUMAN SERUM TRANSFERRIN

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AMIRI ASSGHAR; KAVIRI ZADEH ROYA; RAHIMI POUR MOHAMMAD

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Seminar Paper

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Seminar: IRANIAN INORGANIC CHEMISTRY CONFERENCE
Year:2014 | Issue:16

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Title

BINDING CONSTANTS FOR INDIUM (III) WITH HUMAN SERUM TRANSFERRIN

Author(s)

AMIRI ASSGHAR | KAVIRI ZADEH ROYA | RAHIMI POUR MOHAMMAD

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Abstract

TRANSFERRIN (TF) IS THE BLOOD IRON TRANSPORT PROTEIN WITH TWO GLOBULAR LOBES, THE C-AND N- LOBES, BOTH OF WHICH BIND FE+3[1].INDIUM IS WIDELY USED FOR IMAGING TUMOR CELLS. THE BINDING OF IN+3 TO HUMAN SERUM TRANSFERRIN IN 0.01M HEPES BUFFER, PH 7.4, 5MM SODIUM BICARBONATE AND NITRILOTRIACETIC ACID (NTA) IN RATIO OF 10:1 AT 25OC HAS BEEN STUDIED. INDIUM BINDING CONSTANTS FOR TRANSFERRIN WERE MEASURED BY DIFFERENCE ULTRAVIOLET SPECTROPHOTOMETRY AT 255NM.THE OBSERVED BINDING CONSTANTS ARE LOGK1=17.12± 0.15 AND LOGK2 =15.91± 0.51 THESE CONSTANTS ARE CONDITIONAL CONSTANTS FORPH 7.4 AND 5MM BICARBONATE AND PH DEPENDENT. SINCE BLOOD SERUM TF IS NOT NORMALLY SATURATED WITH IRON, IT HAS AN APPRECIABLE CAPACITY FOR TRANSPORT OF INDIUM (III) IONS THROUGH THE BLOOD.

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APA: Copy

AMIRI, ASSGHAR, KAVIRI ZADEH, ROYA, & RAHIMI POUR, MOHAMMAD. (2014). BINDING CONSTANTS FOR INDIUM (III) WITH HUMAN SERUM TRANSFERRIN. IRANIAN INORGANIC CHEMISTRY CONFERENCE. SID. https://sid.ir/paper/913875/en

Vancouver: Copy

AMIRI ASSGHAR, KAVIRI ZADEH ROYA, RAHIMI POUR MOHAMMAD. BINDING CONSTANTS FOR INDIUM (III) WITH HUMAN SERUM TRANSFERRIN. 2014. Available from: https://sid.ir/paper/913875/en

IEEE: Copy

ASSGHAR AMIRI, ROYA KAVIRI ZADEH, and MOHAMMAD RAHIMI POUR, “BINDING CONSTANTS FOR INDIUM (III) WITH HUMAN SERUM TRANSFERRIN,” presented at the IRANIAN INORGANIC CHEMISTRY CONFERENCE. 2014, [Online]. Available: https://sid.ir/paper/913875/en

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