DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF VINYL ESTER TYPE POLYMERIC PRODRUGS OF SALICYLIC ACID

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Golshaei Parisa; BABAZADEH MIRZAAGHA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Seminar Paper

Paper Information

Seminar: INTERNATIONAL SEMINAR ON POLYMER SCIENCE AND TECHNOLOGY
Year:2014 | Issue:11

Download Full-Text

View:

194

Download:

Information Seminar Paper

Title

DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF VINYL ESTER TYPE POLYMERIC PRODRUGS OF SALICYLIC ACID

Author(s)

Golshaei Parisa | BABAZADEH MIRZAAGHA | Issue Writer Certificate

Keywords

SALICYLIC ACID

CONTROLLED RELEASE

NONSTEROIDAL ANTIINFLAMMATORY DRUGS

POLYMERIC PRODRUGS

Abstract

VINYL ESTER POLYMERIC SYSTEMS LINKED TO SALICYLIC ACID WERE SYNTHESIZED AND EVALUATED AS MATERIALS FOR DRUG DELIVERY. THE CARBOXYL GROUP OF SALICYLIC ACID WAS CONVERTED INTO VINYL ESTER GROUP BY REACTING SALICYLIC ACID WITH VINYL ACETATE IN THE PRESENCE OF MERCURIC ACETATE AS A CATALYST. THE RESULTANT SALICYLIC ACID DERIVATIVE OF VINYL ESTER WAS THEN COPOLYMERIZED WITH 2-HYDROXYETHYL METHACRYLATE OR METHYL METHACRYLATE BY UTILIZING AZOISOBUTYRONITRILE AS AN INITIATOR AT THE TEMPERATURE RANGE OF 65-70OC. THE STRUCTURE OF ALL COMPOUNDS WAS CHARACTERIZED AND CONFIRMED BY FTIR, 1H NMR, AND 13C NMR SPECTROSCOPY TECHNIQUES AND ELEMENTAL ANALYSIS. THE RESULTANT VINYL ESTER TYPE POLYMERIC PRODRUG CONTAINING SALICYLIC ACID WAS HYDROLYZED IN CELLOPHANE MEMBRANE DIALYSIS BAGS CONTAINING AQUEOUS BUFFERED SOLUTIONS AT 37OC AND THE QUANTITY OF THE RELEASED DRUG WAS ANALYZED BY UV SPECTROPHOTOMETER. THE OBTAINED RELEASE PROFILES SHOW THAT DRUG COULD BE RELEASED BY HYDROLYSIS OF THE ESTER BOND AND THE HYDROLYTIC BEHAVIOUR OF THE POLYMERIC PRODRUG IS STRONGLY BASED ON THE PH VALUE OF THE HYDROLYSIS SOLUTION.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

Golshaei, Parisa, & BABAZADEH, MIRZAAGHA. (2014). DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF VINYL ESTER TYPE POLYMERIC PRODRUGS OF SALICYLIC ACID. INTERNATIONAL SEMINAR ON POLYMER SCIENCE AND TECHNOLOGY. SID. https://sid.ir/paper/917862/en

Vancouver: Copy

Golshaei Parisa, BABAZADEH MIRZAAGHA. DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF VINYL ESTER TYPE POLYMERIC PRODRUGS OF SALICYLIC ACID. 2014. Available from: https://sid.ir/paper/917862/en

IEEE: Copy

Parisa Golshaei, and MIRZAAGHA BABAZADEH, “DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF VINYL ESTER TYPE POLYMERIC PRODRUGS OF SALICYLIC ACID,” presented at the INTERNATIONAL SEMINAR ON POLYMER SCIENCE AND TECHNOLOGY. 2014, [Online]. Available: https://sid.ir/paper/917862/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops