Expression of Survivin in the Formalin-Fixed, Paraffin-embedded Specimens of Human Osteosarcoma May Be Used as a Diagnostic Marker

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BABAEI ESMAEIL; Hussen Bashdar Mahmud; ABEDI MARYAM; Jalal Azeez Hewa

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF GENETIC RESOURCES Year:2020 | Volume:6 | Issue:1 Page(s): 49-53

Download Full-Text

Persian Verion

View:

115

Download:

Cites:

Information Journal Paper

Title

Expression of Survivin in the Formalin-Fixed, Paraffin-embedded Specimens of Human Osteosarcoma May Be Used as a Diagnostic Marker

Author(s)

BABAEI ESMAEIL | Hussen Bashdar Mahmud | ABEDI MARYAM | Jalal Azeez Hewa | Issue Writer Certificate

Keywords

Tumor marker

Real-time PCR

FFPE blocks

Immunohistochemistry

Abstract

Osteosarcoma is the most frequent malignant bone tumor with a peak incidence in the second and third decades of life. Diagnosis of patients with osteosarcoma is limited to clinico-pathological parameters whereas molecular markers of tumor initiation and promotion have not yet been identified. We aimed to study the expression of the anti-apoptotic survivin gene in osteosarcoma specimens. A total of 35 formalin-fixed, paraffin-embedded (FFPE) specimens including 25 tumoral and 20 non-tumoral paired-margins were collected. The expression of survivin was evaluated by employing Real-time PCR and Immunohistochemistry. Our data showed that survivin is differently expressed in osteosarcoma samples rather than non-tumoral margins. Real-time PCR showed that survivin is up-regulated in osteosarcoma specimens compared to margins (p<0. 01). Furthermore, IHC confirmed that the survivin protein is significantly found in malignant parts of paraffin blocks. Our data show that survivin expression is modulated in osteosarcoma and may be considered as a diagnostic marker for further studies.

Cites

No record.

References

No record.

Cite

APA: Copy

BABAEI, ESMAEIL, Hussen, Bashdar Mahmud, ABEDI, MARYAM, & Jalal Azeez, Hewa. (2020). Expression of Survivin in the Formalin-Fixed, Paraffin-embedded Specimens of Human Osteosarcoma May Be Used as a Diagnostic Marker. JOURNAL OF GENETIC RESOURCES, 6(1 ), 49-53. SID. https://sid.ir/paper/960208/en

Vancouver: Copy

BABAEI ESMAEIL, Hussen Bashdar Mahmud, ABEDI MARYAM, Jalal Azeez Hewa. Expression of Survivin in the Formalin-Fixed, Paraffin-embedded Specimens of Human Osteosarcoma May Be Used as a Diagnostic Marker. JOURNAL OF GENETIC RESOURCES[Internet]. 2020;6(1 ):49-53. Available from: https://sid.ir/paper/960208/en

IEEE: Copy

ESMAEIL BABAEI, Bashdar Mahmud Hussen, MARYAM ABEDI, and Hewa Jalal Azeez, “Expression of Survivin in the Formalin-Fixed, Paraffin-embedded Specimens of Human Osteosarcoma May Be Used as a Diagnostic Marker,” JOURNAL OF GENETIC RESOURCES, vol. 6, no. 1 , pp. 49–53, 2020, [Online]. Available: https://sid.ir/paper/960208/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops