STUDY OF SIDE EFFECTS AND SOME HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS CHANGES FOLLOWING THE INTRAMUSCULAR INJECTION OF HIGH DOSAGES OF TYLOSIN IN DOGS

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JAFARI SHOURIJEH S.; ANVAR A.R.

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Journal: SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL Year:2006 | Volume:2 | Issue:2 (13) Page(s): 12-22

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Title

STUDY OF SIDE EFFECTS AND SOME HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS CHANGES FOLLOWING THE INTRAMUSCULAR INJECTION OF HIGH DOSAGES OF TYLOSIN IN DOGS

Author(s)

JAFARI SHOURIJEH S. | ANVAR A.R. | Issue Writer Certificate

Keywords

TYLOSINQ3

HEMATOLOGICAL AND BIOCHEMICALQ4

PARAMETERSQ3

SERUMQ2

DOGQ2

Abstract

Twelve healthy native DOGs (six male and six female) aged about 2 years with average body weight of 19±2.6kg were divided randomly into four equal groups (n=3). After clinical examination DOGs were kept in 12 separated cages under similar conditions of temperature, light, ventilation and identical rations of chicken by products for two weeks. The DOGs were treated for parasite elimination during the study. Blood samples were collected from cephalic vein for laboratory examinations before injection of TYLOSIN. In the control group the equal amounts of TYLOSIN in saline solution was injected. The dosages of 25, 75 and 125 mg/kg/day of TYLOSIN were injected for 7 days in the hind limb muscles of each DOG in the first, second and third groups, respectively. Blood samples were collected at different time intervals (3, 7, 14,21 and 28 days) after injection of TYLOSIN and examined for PCV, MCV, MCHC, MCH, WBC, RBC, ALT, AST, CPK, BUN, creatinine, BUN, creatinine and glucose. Data was analyzed statistically by one way ANOVA and Duncan test. Statistical analysis of data indicated significant increase (P<0.05) in ALT, AST and CPK. This increase probably is due to degeneration al changes, hepatocellular destruction, inflammation and muscle damage. Significant decrease in RBC counts, Hb and PCV were observed which could be related to stem cell destruction by high doses of TYLOSIN. It was concluded TYLOSIN had hepatotoxic and myotoxic effects in high doses and causeed liver and muscle damage. In addition to these effects, TYLOSIN can cause anemia due to stem cell destruction.

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APA: Copy

JAFARI SHOURIJEH, S., & ANVAR, A.R.. (2006). STUDY OF SIDE EFFECTS AND SOME HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS CHANGES FOLLOWING THE INTRAMUSCULAR INJECTION OF HIGH DOSAGES OF TYLOSIN IN DOGS. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, 2(2 (13)), 12-22. SID. https://sid.ir/paper/97328/en

Vancouver: Copy

JAFARI SHOURIJEH S., ANVAR A.R.. STUDY OF SIDE EFFECTS AND SOME HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS CHANGES FOLLOWING THE INTRAMUSCULAR INJECTION OF HIGH DOSAGES OF TYLOSIN IN DOGS. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL[Internet]. 2006;2(2 (13)):12-22. Available from: https://sid.ir/paper/97328/en

IEEE: Copy

S. JAFARI SHOURIJEH, and A.R. ANVAR, “STUDY OF SIDE EFFECTS AND SOME HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS CHANGES FOLLOWING THE INTRAMUSCULAR INJECTION OF HIGH DOSAGES OF TYLOSIN IN DOGS,” SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, vol. 2, no. 2 (13), pp. 12–22, 2006, [Online]. Available: https://sid.ir/paper/97328/en

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