MESNA PROTECTIVE EFFECT AGAINST CYCLOPHOSPHAMIDE TOXICITY ON HISTOMORPHOMETRY OF RAT PLACENTA

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REZAEI Z.; MOHAMMADI T.; KHAKSARY MAHABADI M.; NAJAFZADEH VARZI H.; MOHAMMADIAN B.

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Journal: SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL Year:2017 | Volume:13 | Issue:1 Page(s): 52-60

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Title

MESNA PROTECTIVE EFFECT AGAINST CYCLOPHOSPHAMIDE TOXICITY ON HISTOMORPHOMETRY OF RAT PLACENTA

Author(s)

Keywords

MESNAQ1

CYCLOPHOSPHAMIDEQ2

HISTOMORPHOMETRYQ2

PLACENTAQ1

RATQ2

Abstract

Cyclophosphamide is a common chemotherapic medicine but it has toxic side effects.Different medicines are used to prevent its side effects. The aim of this study is evaluation of the protective effects of MESNA against CYCLOPHOSPHAMIDE toxicity in RAT PLACENTA tissue.Fifteen pregnant RATs were randomly divided into 3 groups (1) control (normal saline), (2) CYCLOPHOSPHAMIDE (15 mg/kg), (3) CYCLOPHOSPHAMIDE (15 mg/kg) and MESNA (100 mg/kg).Medicines were administered intraperitoneally on the 13th day of pregnancy. RATs were sacrificed on the 20th day. The PLACENTAe were separated and floated in fixative solution. Five mm PLACENTAl tissue sections were prepared and after staining generally and specially they were studied by light microscopy. CYCLOPHOSPHAMIDE decreased PLACENTAl weight and diameters (P<0.05). Histologically, it induced labyrinth and basal layers thickness reduction (P<0.05) their necrosis and congestion, giant cell number reduction (P<0.05) and their nuclear shrinkage. MESNA has no effect on PLACENTAl morphometry RATher than CYCLOPHOSPHAMIDE (P>0.05) but histologically, increased labyrinth and basal layers thickness and giant cells number (P<0.05). It also prevented nuclear shrinkage and necrosis in giant cells and spongiotrophoblasts in the basal layer and reduce congestion in the labyrinth layer (P<0.05).MESNA sulfhydryl groups possibly react with acrolein, the major factor of CYCLOPHOSPHAMIDE toxicity, and change it to nontoxic compounds. MESNA may protect RAT PLACENTAl tissue against CYCLOPHOSPHAMIDE toxic effects by this mechanism.

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APA: Copy

REZAEI, Z., MOHAMMADI, T., KHAKSARY MAHABADI, M., NAJAFZADEH VARZI, H., & MOHAMMADIAN, B.. (2017). MESNA PROTECTIVE EFFECT AGAINST CYCLOPHOSPHAMIDE TOXICITY ON HISTOMORPHOMETRY OF RAT PLACENTA. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, 13(1), 52-60. SID. https://sid.ir/paper/97406/en

Vancouver: Copy

REZAEI Z., MOHAMMADI T., KHAKSARY MAHABADI M., NAJAFZADEH VARZI H., MOHAMMADIAN B.. MESNA PROTECTIVE EFFECT AGAINST CYCLOPHOSPHAMIDE TOXICITY ON HISTOMORPHOMETRY OF RAT PLACENTA. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL[Internet]. 2017;13(1):52-60. Available from: https://sid.ir/paper/97406/en

IEEE: Copy

Z. REZAEI, T. MOHAMMADI, M. KHAKSARY MAHABADI, H. NAJAFZADEH VARZI, and B. MOHAMMADIAN, “MESNA PROTECTIVE EFFECT AGAINST CYCLOPHOSPHAMIDE TOXICITY ON HISTOMORPHOMETRY OF RAT PLACENTA,” SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, vol. 13, no. 1, pp. 52–60, 2017, [Online]. Available: https://sid.ir/paper/97406/en

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