PROTECTIVE EFFECT OF CONCURRENT ADMINISTRATION OF MESNA AND GALBANUM OIL ON HISTOLOGICAL STRUCTURE OF RAT PLACENTA AGAINST CYCLOPHOSPHAMIDE TOXICITY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOHAMMADI T.; KHAKSARY MAHABADI M.; NAJAFZADEH VARZI H.; REZAI Z.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS) Year:2016 | Volume:16 | Issue:2 Page(s): 211-222

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

601

Download:

Cites:

Information Journal Paper

Title

PROTECTIVE EFFECT OF CONCURRENT ADMINISTRATION OF MESNA AND GALBANUM OIL ON HISTOLOGICAL STRUCTURE OF RAT PLACENTA AGAINST CYCLOPHOSPHAMIDE TOXICITY

Author(s)

MOHAMMADI T. | KHAKSARY MAHABADI M. | NAJAFZADEH VARZI H. | REZAI Z. | Issue Writer Certificate

Keywords

CYCLOPHOSPHAMIDEQ2

GALBANUM OILQ1

MESNAQ1

MORPHOMETRYQ2

HISTOLOGYQ2

PLACENTAQ3

RATQ2

Abstract

Background & objectives: CYCLOPHOSPHAMIDE is one of the common drugs used for cancer treatment. CYCLOPHOSPHAMIDE affects the PLACENTA and it is teratogenic in pregnant women. The purpose of this study was to evaluate the protective effects of MESNA and Galbanum essential oil concurrent administration against CYCLOPHOSPHAMIDE toxicity in RAT PLACENTA tissue.Methods: 22 pregnant female RATs were randomly divided into 3 groups: (1) control (normal saline, n=7 RATs), (2) CYCLOPHOSPHAMIDE (15mg/kg, n=7 RATs), (3) CYCLOPHOSPHAMIDE (15mg/kg), MESNA (100mg/kg) and Galbanum (200mg/kg, n=8 RATs). Medications were administered intraperitoneally on the 13th day of pregnancy. Then, RATs were sacrificed on the 20th day of pregnancy. The PLACENTA was separated and fixed after macroscopic evaluation.5 μm tissue sections were prepared, stained and studied by light microscopy.Results: CYCLOPHOSPHAMIDE reduced the PLACENTAl weight, thickness and the length of the small and large diameters. Histologically, it reduced the thickness of the labyrinth and basal layers, caused necrosis and congestion in these layers, reduced giant cells numbers and caused their nuclear shrinkage (p<0.05). MESNA and GALBANUM OIL had no effect on PLACENTAl MORPHOMETRY RATher than CYCLOPHOSPHAMIDE (p>0.05) but histologically it could increase the labyrinth and basal layers thickness and also the giant cells numbers (p<0.05). It could also prevent nuclear shrinkage, giant cells and spongiotrophoblasts necrosis in the basal layer and reduce congestion in the labyrinth layer (p<0.05).Conclusion: MESNA and GALBANUM OIL preserved the PLACENTA of pregnant RAT against toxic effects of CYCLOPHOSPHAMIDE probably by its antioxidant features and free radicals deletion.

Cites

No record.

References

Cite

APA: Copy

MOHAMMADI, T., KHAKSARY MAHABADI, M., NAJAFZADEH VARZI, H., & REZAI, Z.. (2016). PROTECTIVE EFFECT OF CONCURRENT ADMINISTRATION OF MESNA AND GALBANUM OIL ON HISTOLOGICAL STRUCTURE OF RAT PLACENTA AGAINST CYCLOPHOSPHAMIDE TOXICITY. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 16(2), 211-222. SID. https://sid.ir/paper/60105/en

Vancouver: Copy

MOHAMMADI T., KHAKSARY MAHABADI M., NAJAFZADEH VARZI H., REZAI Z.. PROTECTIVE EFFECT OF CONCURRENT ADMINISTRATION OF MESNA AND GALBANUM OIL ON HISTOLOGICAL STRUCTURE OF RAT PLACENTA AGAINST CYCLOPHOSPHAMIDE TOXICITY. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2016;16(2):211-222. Available from: https://sid.ir/paper/60105/en

IEEE: Copy

T. MOHAMMADI, M. KHAKSARY MAHABADI, H. NAJAFZADEH VARZI, and Z. REZAI, “PROTECTIVE EFFECT OF CONCURRENT ADMINISTRATION OF MESNA AND GALBANUM OIL ON HISTOLOGICAL STRUCTURE OF RAT PLACENTA AGAINST CYCLOPHOSPHAMIDE TOXICITY,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 16, no. 2, pp. 211–222, 2016, [Online]. Available: https://sid.ir/paper/60105/en

Related Journal Papers