PRODUCTION AND QUALITY CONTROL OF 175YB-EDTMP FOR PAIN PALLIATION OF BONE METASTASES

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SAFARZADEH L.; GHANNADI MARAGHEH M.; ANVARI A.; AGHAMIRI S.M.R.; SHIRVANI ARANI S.; BAHRAMI SAMANI A.

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Journal: JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY Year:2013 | Volume:- | Issue:2 (64) Page(s): 48-55

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Title

PRODUCTION AND QUALITY CONTROL OF 175YB-EDTMP FOR PAIN PALLIATION OF BONE METASTASES

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Keywords

BONE METASTASESQ2

175YBQ2

RADIOPHARMACEUTICALQ2

EDTMPQ2

BIODISTRIBUTIONQ2

Abstract

Bone metastasis is a major consequence of several cancers. The prostate, breast, lung cancers are mostly associated with the bone pain. Different radioisotopes are used for the bone pain palliation. 175Yb is proposed as a proper alternative to other radioisotopes due to its relatively long half-life (T1/2=4.18 days), maximum energy beta particle Eb-=470 keV (86%), low abundance gamma emission, low cost, and easy production. In this study, 175Yb was obtained by thermal neutron bombardment of a natural 174Yb2O3 sample in the 5MW Tehran Research Reactor (TRR). The radionuclide purity of the 175Yb was ascertained by recording gamma ray spectra using a gamma spectrometer with a HPGe detector. Radiolabeling was completed in one hour by the addition of EDTMP at room temperature and pH=8-9. The quality control and BIODISTRIBUTION studies were carried out in normal wild-type rats. The radiochemical purity was determined by ITLC and the results were found to be higher than 99%. This study showed favorable BIODISTRIBUTION features of 175Yb-EDTMP which are indicating its significant accumulation in the bone. Also, it was observed that clearance of the activity from other organs accrued after 4 days. This research presents 175Yb-EDTMP as a suitable RADIOPHARMACEUTICAL with a proper half-life and low dose for the bone palliation of skeletal metastases.

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APA: Copy

SAFARZADEH, L., GHANNADI MARAGHEH, M., ANVARI, A., AGHAMIRI, S.M.R., SHIRVANI ARANI, S., & BAHRAMI SAMANI, A.. (2013). PRODUCTION AND QUALITY CONTROL OF ¹⁷⁵YB-EDTMP FOR PAIN PALLIATION OF BONE METASTASES. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, -(2 (64)), 48-55. SID. https://sid.ir/paper/97982/en

Vancouver: Copy

SAFARZADEH L., GHANNADI MARAGHEH M., ANVARI A., AGHAMIRI S.M.R., SHIRVANI ARANI S., BAHRAMI SAMANI A.. PRODUCTION AND QUALITY CONTROL OF ¹⁷⁵YB-EDTMP FOR PAIN PALLIATION OF BONE METASTASES. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY[Internet]. 2013;-(2 (64)):48-55. Available from: https://sid.ir/paper/97982/en

IEEE: Copy

L. SAFARZADEH, M. GHANNADI MARAGHEH, A. ANVARI, S.M.R. AGHAMIRI, S. SHIRVANI ARANI, and A. BAHRAMI SAMANI, “PRODUCTION AND QUALITY CONTROL OF ¹⁷⁵YB-EDTMP FOR PAIN PALLIATION OF BONE METASTASES,” JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, vol. -, no. 2 (64), pp. 48–55, 2013, [Online]. Available: https://sid.ir/paper/97982/en

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