Lithium preprations have been used in bipolar mood disorders since 19th Centary.Lethal toxic effect of lithium due to it's narrow (therapeutic) index had been known from Several years ago and is the most problem when is prescribed.Serum level of lithium is accepted for monitoring of toxicity, but frequency of blood testing especially in stabilizing period is stressful for patients, also it is difficult in such psychiatric patients especially in children.Many reaserchers worked to find a less aggressive method one of this methods is monitoring based on salivary lithium concentration, which is contraversy according to this review articles. All papers from 1949 till now revewed in this article and revealed this controversy.According to review article; tree ways being suggested to solve this problem 1- Stimation of salivary – serum ratio of lithium based on tree seprated paired tests 2- Improve methods and techniques of testing. 3- Modifing of this ratio based on natural markers.

Aim and Background: Mood disorders are a significant group of psychiatric disorders. Bipolar spectrum disorders are mood disorders that usually remain unrecognized and subsequently undertreated. One of the most useful screening instruments for underdiagnosed bipolar disorders is the Mood Disorder Questionnaire (MDQ). This paper presented the Persian version and psychometric properties of MDQ for patients with mood disorder in Isfahan, Iran.Methods and Materials: A total number of 62 patients with mood disorders were selected using convenience sampling. The subjects completed the MDQ before being interviewed using the Composite International Diagnostic Interview. The control group was selected according to psychiatric interviews and the General Health Questionnaire. A demographic questionnaire and the MDQ were administered to both groups. Data was analyzed by descriptive statistics, factor and differentiation analyses, and Cronbach's alpha and Spearman correlation coefficient tests in SPSS13.Findings: The reliability of the whole questionnaire was α=0.81. Each question showed an internal positive consistency with the whole questionnaire (0.18-0.64). The cut-off point was determined to be 8.5 based on the differentiation analysis (sensitivity=0.67 and specificity=0.76). The factor analysis using major elements and varimax rotation resulted in three factors.Conclusions: Our findings showed that the MDQ had appropriate psychometric properties in our sample.This questionnaire can be used in screening by the health centers of Iran.

Background & Aim: Mood disorders refer to a category of mental problems which intensively affect the person's mood quality and change his perception of self and the environment. The aim of the present study was to assess the effects of an eight-week resistance activity on mood disorders (depression and mania) in secondary education students of Yasouj, Iran.Methods: The present research was a quasi-experimental field study. The statistical population of the research included all male secondary education students of Yasouj city, and among the main population, 854 students were selected using cluster-random sampling. A questionnaire was filled up for by each student. Twenty four of the students showed symptoms of depression or mania. The depressed students randomly set in two groups with 9 samples (case & control) and manic students set in two groups with 3 samples in each group. Two subscales of depression and mania, and Minnesota multiphasic questionnaire (MMPI-A) were used in this study. Having completed the pretest, the experimental group completed a course of endurance exercise for 8 weeks, including three 50-minute sessions per week with intensity of 55 to 65% of maximum consuming energy, while the control group had no physical exercise. Finally, four groups were given post tests. The collected data were analyzed using dependent and independent t-test.Results: A significant difference between the mean score of depression and mania in pretest and posttest of the experimental group was seen. Also there was a significant difference between the mean score of depression of the experimental and control groups after intervention (p<0.001), whereas the mean scores of mania between the two groups weren' t statistically significant (p>0.05).Conclusion: It can be mentioned that resistance exercises have a significant effect on lessening depression and mania, and this decrease is much more sensible in depression disorder than mania