AMIDES HAVE BEEN SYNTHESIZED PROFICIENTLY WITH MINIMAL BY-PRODUCTS BY OPERATING A ONE POT OXIDATIVE AMIDATION OF BENZYL ALCOHOLS WITH AMINE HYDROCHLORIDE SALTS [1-4]. THIS GREENER AMIDE FORMATION PROCESS HAS BEEN DEVELOPED USING MAGNETIC INORGANIC–ORGANIC HYBRID CATALYST FE3O4@EDTA@CUCL2, BASE PROMOTER AND TBHP AS OXIDANT. THE CATALYST HAS BEEN CHARACTERIZED BY FT-IR, XRD, SEM, VSM, ICP AND TG/DTA. THE MEASURED CONTENT OF CU IN FE3O4@EDTA@CUCL2 BY INDUCTIVELY COUPLED PLASMA ATOMIC EMISSION SPECTROSCOPY (ICP-AES) WAS 0.4 MMOL PER GRAM OF CATALYST. AMIDE DERIVATIVES WERE OBTAINED IN HIGH YIELDS VIA A ONE-POT REACTION TACTIC. AFTER REACTION BY AID OF EXTERNAL MAGNET, THE CATALYST COULD BE EXCRETED FROM THE REACTION VESSEL AND REUSED AT LEAST SIX TIMES WITHOUT DECREASING OF ITS ACTIVITY.

IODINE IS MOST STABLE WITH AN OXIDATION STATE -1; HOWEVER, IT FORMS STABLE POLYCOORDINATE, MULTIVALENT COMPOUNDS.CURRENT RESEARCHES FOCUS ON ITS USE IN CARBON-CARBON AND CARBONHETEROATOM BOND FORMING REACTIONS...

AMIDE BOND LINKAGE IS A WORLDWIDE AND IMPORTANT CORE STRUCTURE IN PHARMACEUTICAL, CHEMICAL, AND MANY NATURAL PRODUCTS. MANY PROCEDURES FOR THE FORMATION OF AMIDES ARE KNOWN IN THE LITERATURE [1-6]. THE MOST COMMON METHODS ARE THE REACTION BETWEEN CARBOXYLIC ACID DERIVATIVES PARTICULARLY ACID...

RAW AND OXIDIZED CARBON NANOTUBES (CNTS) UNABLE TO ADSORPTION OF HG (II) IONS. THEN CARBON NANOTUBES WERE OXIDIZED WITH HNO3 AND OXIDIZED CNTS WERE AMIDIZED WITH AMMONIUM ACETATE SOLVED IN ACETONITRILE. THEIR PHYSICOCHEMICAL PROPERTIES WERE INVESTIGATED BOEHM’S TITRATION, RAMAN SPECTROSCOPY, FT-IR, THERMAL ANALYSIS (TGA & DTA) AND ZETA POTENTIAL MEASUREMENT. IN THIS WORK, AMIDIZED CNTS USED AS A NEW ADSORBENT FOR SOLID PHASE EXTRACTION (SPE) OF HG (II) FROM AQUEOUS SOLUTIONS. THE EFFECT OF PH, TYPE OF BUFFER AND FLOW RATE FOR QUANTITATIVE ENRICHMENT WAS ALSO INVESTIGATED. THE EXPERIMENTAL RESULTS SUGGEST THAT HG (II) ADSORPTION CAPACITIES AMIDIZED CNTS INCREASE DUE TO THE FUNCTIONAL GROUPS INTRODUCED BY OXIDATION COMPARED WITH THE AS-GRAWN CNTS. A DETECTION LIMIT OF 5.00×10-4 NG/ML AND A RELATIVE STANDARD DEVIATION 2.4% WERE OBTAINED. THE CNT–SPE PRECONCENTRATION PROCEDURE SHOWED A LINEAR CALIBRATION CURVE WITHIN CONCENTRATION RANGE FROM 0.003 TO 0.3 NG/ML FOR HG (II).

BACKGROUND: THE AMIDE BOND FORMATION IS OF ENORMOUS INTEREST IN ORGANIC SYNTHESIS OF NATURAL PRODUCTS, POLYMERS AND PHARMACEUTICALS. SOME COMMON DRAWBACKS ASSOCIATED WITH THESE METHODS SUCH AS POOR ATOM EFFICIENCY AND USE OF HAZARDOUS REAGENTS HAVE LED RESEARCHERS TO CONSIDER ALTERNATIVE METHODS. WE REPORT CU-CATALYZED DIRECT OXIDATIVE AMIDATION OF BENZYL ALCOHOL WITH AMINES.METHODS: THIS GREENER AMIDE FORMATION PROCESS HAS BEEN DEVELOPED USING MAGNETIC INORGANIC–ORGANIC HYBRID CATALYST FE3O4@EDTA@CUCL2 BASE PROMOTER AND H2O2 AS OXIDANT. THE CATALYST HAS BEEN CHARACTERIZED BY FT-IR, XRD, SEM, VSM, ICP AND TG/DTA. THE MEASURED CONTENT OF CU IN FE3O4@EDTA@CUCL2 BY INDUCTIVELY COUPLED PLASMA ATOMIC EMISSION SPECTROSCOPY (ICP-AES) WAS 0.4 MMOL PER GRAM OF CATALYST.RESULTS: AMIDE DERIVATIVES WERE OBTAINED IN HIGH YIELDS VIA A ONE-POT REACTION TACTIC. AFTER REACTION BY AID OF EXTERNAL MAGNET, THE CATALYST COULD BE EXTRACTED FROM THE REACTION VESSEL AND REUSED AT LEAST SIX TIMES WITHOUT DECREASING OF ITS ACTIVITY.

METAL-CATALYZED AMIDATION REACTIONS OF ARYL HALIDES ARE AN ATTRACTIVE METHOD FOR SYNTHESIZING N-ARYLAMIDES. PREVIOUSLY, THE AMIDATIONS OF ARYL HALIDES HAVE BEEN PERFORMED USING ULLMANN-TYPE CONDITIONS USING STOICHIOMETRIC METAL AND HIGH REACTION TEMPERATURES. RECENT ADVANCES IN THIS AREA HAVE ALLOWED FOR THE REACTIONS OF AMIDES AND ARYL IODIDES OR ARYL BROMIDES TO BE PERFORMED USING CATALYTIC AMOUNTS OF METAL UNDER MILDER CONDITIONS. [1-3]AMIDES ARE WEAK NUCLEOPHILES AND WITHOUT METAL CATALYST COULDN' T PARTICIPATE IN THE COUPLING REACTIONS. HEREIN, WE HAVE DEVELOPED THE PALLADIUM-CATALYZED SYNTHESIS OF N-ARYLAMIDES BY N-ARYLATION OF AMIDES AND ARYL HALIDES USING PALLADIUM XANTPHOS COMPLEXE [PDCL2 (XANTPHOS)] AS A EFFICIENT CATALYST.