Multiple endocrine neoplasia type 1 (MEN-1), also known as Wermer syndrome, is an autosomal dominant disorder characterized by the combined occurrence of two or more tumors (classically parathyroid, pancreatic, and pituitary). Due to the rarity of MEN-1 syndrome and its complexity, clinical management is difficult, and it is recommended to collaborate with a professional team including: clinical geneticist, endocrinologist, gastroenterologist, oncologist, endocrinologist, neurosurgeon, radiologist, and histopathologist. Here, a case of a young patient with MEN-1 syndrome is introduced, who was admitted to the Persian Gulf Martyrs Hospital in Bushehr due to hypercalcemia. The patient had a history of lipoma in childhood and currently has tumoral involvement of all three classic glands of this syndrome.

Medullary thyroid carcinoma (MTC) occurs both sporadically and in the autosomal dominantly inherited multiple endocrine neoplasia (MEN) type 2 syndromes. The distinction between true sporadic MTC and a new mutation familial case is important for future clinical management of both the patient and family. The susceptibility gene for hereditary MTC is the RET proto-oncogene. DNA analysis for germline mutations of the RET proto-oncogene was performed in a series of 24 patients with MTC [apparently sporadic MTC (20 cases), familial MTC (2 cases), MEN 2A (one case) and MEN 2B (one case)] to determine whether they were true sporadic cases or hereditary forms. Genomic DNA was amplified using polymerase chain reaction (PCR) and oligonucleotide primers for exons 10 & 11. The PCR products were examined by restriction enzymes analysis to detect the mutations. One of the 20 patients with apparent sporadic MTC had exon 10 mutation (Cys620 Arg); and exon 11 mutation (Cys-634 Trp) was also found in index case with MEN 2A. No mutation was detected in the other patients. Three of six evaluated members of the MEN 2A patients had the same mutation. We conclude routine application of RET proto-oncogene testing should be included in all cases of apparent sporadic MTC.

Introduction: The pancreatic endocrine tumors are rare. Insulinoma is the most common pancreatic endocrine neoplasm.30% of pancreatic tumors in MEN type I are beta cell tumors.Case Report: The presented case is a 23 year old male with a family history of MEN I syndrome. The patient  presented with whipple triad. Radiologic studies revealed two small and round masses in body and tail of pancreas. With clinical diagnosis of pancreatic tumor the patient underwent laparatomy, distal pancreatectomy and splenectomy.Conclusion: According to macroscopic, microscopic, immunostaining findings, clinical and laboratory data the final diagnosis was insulinoma.

Introduction: Rumination is one of the factors which can significantly impact the mental health and life quality of the elderly. Thus, this study examined the effectiveness of cognitive problem-solving strategies on rumination among elderly men in the province of Kermanshah, Iran. Method: The study adopted a quasi-experimental method with pre-test, post-test, and control/experimental groups design. The statistical population included the entire elderly men attending Mah psychology clinic where they reported suffering from rumination. The results of psychological tests also confirmed their declarations. The participants constituted 24 men with the age range of 60 to 65. They were selected through the convenience sampling method and the study criteria and randomly assigned to one control group (n= 12) and one experimental group (n= 12). Initially, a pre-test was administered to both groups. Moreover, the experimental group underwent eight 45-minute sessions of training cognitive problem-solving strategies. To measure rumination, the Ruminative Response Scale developed by Nolen-Hoeksema and Morrow (1991) was employed. The data were analyzed using the analysis of covariance (ANCOVA), the results of which suggested a significant difference between the rumination mean scores of the two groups in the post-test. This implies that the intervention of cognitive problem-solving strategies led to a significant reduction in rumination up to 35 percent. Results: In light of the results, the instruction of cognitive problem-solving strategies can considerably reduce rumination thereby increasing the feeling of life satisfaction. Conclusion: This approach may be fruitful in terms of reducing rumination and promoting life quality among the elderly.