BACKGROUND: SUBSTITUTED POLYHYDROQUINOLINE AND 1, 4-DIHYDROPYRIDINES (1, 4-DHPS) HAVE ATTRACTED CONSIDERABLE INTEREST BECAUSE THEY POSSESS VARIOUS BIOLOGICAL ACTIVITIES [1]. THEY ARE GENERALLY PREPARED BY CLASSICAL HANTZSCH METHOD, WHICH INVOLVES CONDENSATION OF A B-KETOESTER ALDEHYDE, AS WELL AS AMMONIA IN ACETIC ACID OR IN REFLUXING ALCOHOL [2]. SEVERAL CATALYSTS SUCH AS BAKERS' YEAST [3], SILICA GEL/NAHSO4 [4], YB (OTF)3 [5], AND SO ON TO IMPROVE THE REACTION YIELDS...

MULTI COMPONENT REACTIONS ALLOW THE REACTION OF SEVERAL BONDS IN SINGLE OPERATION AND ARE ATTRACTING INCREASING ATTENTION AS ONE OF THE MOST POWERFUL EMERGING SYNTHETIC TOOLS FOR THE CREATION OF MOLECULAR DIVERSITY AND COMPLEXITY.1 IN RECENT YEARS, MUCH ATTENTION HAS BEEN DEVOTED TO THE SYNTHESIS OF POLYHYDROQUINOLINE COMPOUNDS DUE TO THEIR DIVERSE THERAPEUTIC AND PHARMACOLOGICAL PROPERTIES, SUCH AS VASODILATOR, ANTITUMOR, BRONCHODILATOR, ANTIARTHEROSCLEROTIC, GEROPROTECTIVE AND HEPATOPROTECTIVE ACTIVITY…

NANOTECHNOLOGY IS OF GROWING IMPORTANCE IN MANY BRANCHES OF RESEARCH BECAUSE OF THE OPPORTUNITY FOR MINIATURIZATION AND THE INTERESTING PROPERTIES ASSOCIATED WITH SMALL PARTICLE SIZE [1]. NANOPARTICLES HAVE GREAT POTENTIAL FOR USE AS A CATALYST FOR A VARIETY OF ORGANIC AND INORGANIC REACTIONS DUE TO THEIR HIGH SURFACE TO VOLUME RATIO.BOEHMITE IS USED AS CATALYST AND CATALYST SUPPORT, MAINLY DUE TO ITS GOOD THERMAL STABILITY, HIGH SPECIFIC SURFACE AREA, SURFACE ACIDITY AND THE INTERACTION WITH DEPOSITED TRANSITION METALS.4-SUBSTITUTED 1, 4-DIHYDROPYRIDINES (1, 4-DHPS) ARE WELL KNOWN AS CA2+ CHANNEL BLOCKERS, AND HAVE EMERGED AS ONE OF THE MOST IMPORTANT CLASSES OF DRUGS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES [2]. THE DHP HETEROCYCLIC RING IS A COMMON FEATURE OF VARIOUS BIOACTIVE COMPOUNDS ANTITUMOR, GEROPROTECTIVE, HEPATOPROTECTIVE, AND ANTIDIABETIC AGENTS [3].IN THIS WORK WE BECAME INTERESTED OF DEVELOPING A ONE-POT SYNTHESIS OF POLYHYDROQUINOLINE DERIVATIVES THROUGH THE HANTZSCH A FOUR COMPONENT COUPLING REACTION OF ALDEHYDES, DIMIDONE, ETHYL ACETOACETATE, AND AMMONIUM ACETATE IN THE PRESENCE OF BOEHMITE NANOPARTICLES. BOEHMITE NANOPARTICLES WAS PREPARED FROM AL (O-SEC-BU) 3 BY REACTION WITH WATER VAPOR IN A HYDROTHERMAL CHAMBER.

NANOTECHNOLOGY IS OF GROWING IMPORTANCE IN MANY BRANCHES OF RESEARCH BECAUSE OF THE OPPORTUNITY FOR MINIATURIZATION AND THE INTERESTING PROPERTIES ASSOCIATED WITH A SMALL PARTICLE SIZE [1]. IN RECENT DECADES, NANOSTRUCTURE MATERIALS HAVE ATTRACTED MUCH ATTENTION FOR THEIR NOVEL ELECTRONIC, ...

POLYHYDROQUINOLINE (PHQ) AND 1, 4-DIHYDROPYRIDINE (DHP) DERIVATIVES CONTAIN A LARGE FAMILY OF MEDICINALLY IMPORTANT COMPOUNDS THAT HAVE ATTRACTED MUCH ATTENTION BECAUSE OF THEIR DIVERSE PHARMACOLOGICAL AND THERAPEUTIC PROPERTIES. IN VIEW OF THE BIOLOGICAL, INDUSTRIAL AND SYNTHETIC IMPORTANCE OF THESE COMPOUNDS, SEVERAL METHODS FOR THEIR SYNTHESIS HAVE BEEN REPORTED. …

POLYHYDROQUINOLINES AND THEIR DERIVATIVES (DHPS) HAVE RECEIVED CONSIDERABLE ATTENTION OF SYNTHETIC AND MEDICINAL CHEMISTS BECAUSE OF THEIR BROAD SPECTRUM OF BIOLOGICAL AND PHARMACEUTICAL ACTIVITIES. THESE DERIVATIVES SHOW ANTIHYPERTENSIVE, VASODILATOR, ANTIMUTAGENIC, ANTITUMOR, ANTICONVULSANT, ANTIDIABETIC, ANTIANXIETY, ANTIDEPRESSIVE, ANALGESIC, SEDITATIVE, BRONCHODILATOR, HYPNOTIC AND ANTI-INFLAMMATORY ACTIVITIES.RECENTLY, THE USE OF SOLID SUPPORTED CATALYSTS HAS RECEIVED CONSIDERABLE IMPORTANCE IN ORGANIC SYNTHESIS BECAUSE OF THEIR EASE OF HANDLING, REDUCED REACTION TIMES, GREATER SELECTIVITY, SIMPLE WORKUP, AND RECOVERABILITY OF THE CATALYSTS. WITH THIS GOAL IN MIND HEREIN, AMORPHOUS NANOSILICA WAS SUCCESSFULLY EXTRACTED FROM RICE HUSK (RH-SIO2), FUNCTIONALIZED WITH PROPYLAMINE GROUPS (RHPRNH2) AND USED AS A BASIC CATALYST FOR THE SYNTHESIS OF POLYHYDROQUINOLINE DERIVATIVES VIA THE HANTZSCH REACTION UNDER SOLVENT FREE CONDITIONS, THE CATALYST HAS HIGH ACTIVITY THE MAIN ADVANTAGE OF THE PRESENT APPORACH ARE SHORT REACTION TIMES, HIGH YIELDS, CLEAN REACTION PROFILES, SIMPLE EXPERIMENTAL AND WORK-UP PROCEDURE.