Introduction: In this study, we intend to investigate the effect of continuous-release tamsulosin tablets and tamsulosin capsules on ejaculation. Methods: This study was performed on 120 patients. 66 patients as control group were treated with tamsulosin 0. 4 mg capsules and 54 patients were treated with tamsulosin 0. 4 mg continuous release tablets and patients were asked about whether or not they had the inability to ejaculate. Results: The case group consisted of 54 people and the control group consisted of 66 people respectively. The test results indicated that the frequency of ejaculation in the case group and the control group was not significantly different (p= 0. 096). Twenty-seven patients had a history of non-ejaculatory complication due to tamsulosin usage (12 of them were in the case group and 15 of them were in the control group). Eight patients in the case group and 4 patients in the control group gained complete recovery from the inability to ejaculate. Therefore, we can conclude that it had a significant difference (p=0. 038) Conclusion: In this study, despite the fact that there was no significant difference in the incidence of no ejaculation, slow-release tamsulosin tablets could improve this complication in people with a history of tamsulosin usage.

Introduction: We evaluated the effectiveness of tamsulosin and nifedipine during watchful waiting in patients with juxtavesical ureteral stone. Materials and Methods: Between Oct 2003 and Feb 2004, 382 patients with renal colic referred to our center which 64 patients suffered from juxtavesical stone less than 1 cm where enrolled in the study and were randomly divided into 3 groups. The average sizes of the stones were 6.7 mm, 6.4 mm, 6.8 mm in Groups 1, 2, 3. Group 1 (20 Patients) received daily oral treatment of 0.4 mg tamsulosin and group 2 (20 Patients) received 20 mg nifedipine daily oral therapy, group 3 (24 Patients) were used as controls. The patients were treated about 4 weeks and the patients were every 1 week and sonography was done for 4 weeks and whenever the stone was expulsed, we discounted the drug. Information about stones passage and time and complication was noted. Statistical analyses were performed with using the K2test. Results: We had 35 males and 29 females patients with mean age of38 years. According to patients age, sex and stone size there was no significant difference between 3 groups. The stone passage rate was 90% (8 Patients), 75% (14 Patients) and 45% (11 Patients) in groups 1, 2, 3 respectively. The difference in group 1 and 2 with respect to group 3 was significant. Average expulsion time was 16 days, 20 days and 18 days in 3 groups respectively. A statistically significant difference was noted between group I and 3. Two patients from group I, five patients from group 2 and thirteen patients from group 3 underwent transurethral lithotripsy. Conclusions: Tamsulosin and nifedipine administration in renal colic due to juxtavesical calculi increased the stone expulsion rate, reduced expulsion time and decreased need for hospitalization and endoscopic procedures.

Background &Aims: Impacted distal ureteral stone have always been controversial on the choice of treatment. This study aims to evaluate the effect of tamsulosin (non selective alpha 1-blocker) in medical expulsion therapy of distal ureteral stones.Materials &Methods: 96 patients with UVJ or distal ureteral stones (size between 3-6 mm) were randomly divided into two groups. Group 1 (46 patients – the control group) received only indomethacin (100 mg /PRN). Group 2 (50 patients) received indomethacin and tamsulosin (0.4 mg daily). All patients were questioned about the episodes of ureteral colic, dose of Indomethacin, rate and time of spontaneous passage of stones. Patients were followed for 28 days.Results: 30 of 46 patients (62.5%) in the control group and 41of 50 patients (82%) in tamsulosin group had spontaneous stone passage during 28 days. The expulsion rate were not significantly different between 2 groups (P>0.05). Stone expulsion time was 8.03±4.7 days in control group and 5.07±3.7days in tamsulosin group. This difference was statistically significant (P<0.05). The control group had more ureteral colic episodes and more indomethacin use rather than tamsulosin group. This difference was statistically significant (P=0.05).Conclusion: Tamsulosin decreases the duration of stones passage, severity of pain and use of analgesics in conservative management of distal ureteral stones , but doesn’t increase the frequency of spontaneous passage of the distal ureteral calculi significantly.

Introduction: Urinary stones are among the most prevalent urological diseases (1-15%). While passing from kidneys to bladder, these stones stay in the lower urethra, causing painful spasms. Watchful waiting method (between 1-6 weeks) is one of the most common remedies in the treatment of lower urethral stones on the other hand, a-receptors, which help with controlling the spasm, exist in the distal urethras, especially in the trigone of the bladder. So, we decided to study the effects of Tamsulosin (a-blockers), as compared to Indomethacin, on patients suffering from distal urethral stones. The objective of this study is to evaluate the effect ofα-blocker (Tamsulosin) on the expulsion of lower urethral stones in the patients who referred to Bahman 22nd and Aria hospitals in one year.materials and methods: 85 patients who were diagnosed as suffering from urethral stones were randomly divided into 2 groups.46 patients who were placed in the first group received Tamsulosin (0.4 mg/daily) with suppository of Indomethacin for 10 days. The other 39 patients in the second group received only Indomethacin. After taking the prescribed medicines, the patients were again examined and controlled by KUB and Ultrasound. Then, the results were compared using statistical analysis.results: 32 of the patients in the first group (the case) who had received Tamsulosin had stone expulsion while the other 14 patients did not. Among the patients in the control group (a total of 39), 22 patients had stone expulsion while 17 patients did not. The result of chi-square test revealed that the 2 groups were not significantly different from each other in terms of stone expulsion and prognosis (P=0.209).There were no statistical differences between the groups of study according to age, gender and the stone size, either.conclusion: According to these findings, we do not suggest the prescription of Tamsulosin as an adjuvant therapy for stone expulsion in patients who have lower ureteral stone without considering their stone size and gender. Instead, just prescribing pain relief (if necessary) and physical activity with large amount of oral liquid intake during the watchful waiting period are enough.

Background and Objectives: Ureteral stones are important conditions which are observed primarily or secondarily after ESWL or PNL. They cause obstruction of urinary tract and Intervention for stone release also has some complication. The aim of this study was to evaluate the efficacy of the addition of Tamsulosin to traditional expulsive therapy for the treatment of distal-ureteral stones and release of obstruction.Material and Methods: Between march 2005 until march 2006 a series of 36 patients randomly were included in one clinical trial study for the management of symptomatic distalureteral calculi .they randomly divided into group 1 (N=18) who received indomethacin and hydrochlorotyazid and group 2 (N=18) who received the same therapy plus Tamsulosin (0.4 mg/daily). There were no differences between the groups with respect to age, sex, or stone size.The primary endpoint was the expulsion rate. Need for analgesics and hospitalization, were the secondary endpoints.Results: Group 1 (control): 13male, 5female .Group2:14 male, 4female. The expulsion rate was significantly higher in group 2 than in group 1, (87.5% versus50%) (P<0.05) and Lower analgesics use was found in group 2, as well as significantly fewer hospitalization for recurrent renal colic (11.1%versus 82.4%). Both groups experienced few side effects associated with expulsive therapy.Conclusion: In conservative management of uncomplicated distal-ureteral stones, Tamsulosin can increase stone expulsion rate and decrease need to analgesics and hospitalization.

Introduction: Acute urinary retention due to benign prostatic enlargement is one of the clinical complaints that patients refer to the emergency department. Selective α-blockers are used after urinary catheterization. Recently, the use of nitrate compounds has been shown to relieve bladder neck and to treat acute urinary retention. Objective: The aim of this study was to survey the addition of Isosorbide di nitrate to tamsulosin in the treatment of acute urinary retention in patients with benign prostatic hyperplasia. Methods: This is a randomized, double-blind placebo-controlled clinical trial. In all, 78 patients with benign prostatic hyperplasia-related acute urinary retention referred to the emergency department were divided into two groups and randomly assigned to receive either 0. 4  mg tamsulosin plus placebo or 0. 4  mg tamsulosin plus isosorbide dinitrate 40 mg extended-release tablets daily for 3  days. At the same first visit, the catheter was removed and the ability to void in same time and 1  month later was assessed in each group. Results: After catheter removal, 27 (67. 5%) patients in the tamsulosin plus placebo group and 31 (81. 6%) in the tamsulosin plus isosorbide dinitrate group voided successfully after 3 days  (p  =  0. 155). After 1  month, 20 (50. 0%) patients taking tamsulosin plus placebo and 23 (60. 5%) taking tamsulosin plus isosorbide dinitrate could void, yet indicating no significant difference (p  =  0. 350). Conclusions: Addition of isosorbide dinitrate to α-blockers has advantage in improving benign prostatic hyperplasia-related acute urinary retention versus tamsulosin alone, although was not statistically significant.

In this study a sensitive, simple and accurate spectrophotometric method was suggested for determination of tamsulosin in bulk powder and pharmaceutical dosage form based on the formation of an ion-pair complex between the drug and bromocresol green in a buffer solution at pH 3.5. The formed yellow color complex was extracted with chloroform and measured at 415 nm. The optimum reaction conditions such as pH, reagent amount, extracting solvent and the stoichiometry of the ion-pair complex were investigated. Under the optimized conditions, the Beer’s law was obeyed in the concentration range of 1-160 mg/mL with acceptable correlation coefficient (r2>0.9997) and precision (CV<3%) and accuracy (error 2%). The proposed method was successfully used for the determination of tamsulosin in pharmaceutical capsule with no significant interferences of excipients.

Background: Tamsulosin is an inhibitory factor of alpha-adrenergic receptors that is used for relieving of the clinical symptoms and management of acute urinary retention. Objective: The aim of this study was to evaluate the effects of tamsulosin on the endocrine axis and testicular tissue in adult male rats. Materials and Methods: In this experimental study, 30 adult male Wistar rats (weighing 250-300 gr) were divided into three groups: 1) control (received distilled water), 2) experimental 1 (received 0. 2 mg/kg/day tamsulosin) and 3) experimental 2 (received 0. 4 mg/kg/day tamsulosin) through oral gavage for 28 days. Serum hormones level and testicular histopathology were evaluated at the end of the experiment. Results: In this study, the testicular weight decreased significantly in the experimental groups compared to the control group. A significant decrease was seen in testicular weight (p = 0. 004) and the number of Leydig cells in tamsulosin-treated groups (p = 0. 012). Tamsulosin improved the hormone profile in experimental groups. Also, higher dose of tamsulosin significantly changed the number of Leydig, spermatogonia cells, the thickness of germinal layer, and the diameter of the seminiferous tubules. Conclusion: Results showed that using tamsulosin, possibly reduces the testosterone concentration through adrenergic axis system and in turn has destructive effects on proliferative activity of germ cells.