VALIDATED SPECTROPHTOMETRIC METHOD FOR DETERMINATION OF TAMSULOSIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS

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AMANLOU MASSOUD; GHAZI MOGHADAM AMIN; BARAZANDEH TEHRANI MALIHEH; SOURI EFFAT

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Paper Information

Journal: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH Year:2014 | Volume:13 | Issue:1 Page(s): 81-86

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Title

VALIDATED SPECTROPHTOMETRIC METHOD FOR DETERMINATION OF TAMSULOSIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS

Author(s)

AMANLOU MASSOUD | GHAZI MOGHADAM AMIN | BARAZANDEH TEHRANI MALIHEH | SOURI EFFAT | Issue Writer Certificate

Keywords

TAMSULOSIN

BROMOCRESOL GREEN

SPECTROPHOTOMETRY

ION-PAIR COMPLEX

Abstract

In this study a sensitive, simple and accurate spectrophotometric method was suggested for determination of tamsulosin in bulk powder and pharmaceutical dosage form based on the formation of an ion-pair complex between the drug and bromocresol green in a buffer solution at pH 3.5. The formed yellow color complex was extracted with chloroform and measured at 415 nm. The optimum reaction conditions such as pH, reagent amount, extracting solvent and the stoichiometry of the ion-pair complex were investigated. Under the optimized conditions, the Beer’s law was obeyed in the concentration range of 1-160 mg/mL with acceptable correlation coefficient (r2>0.9997) and precision (CV<3%) and accuracy (error 2%). The proposed method was successfully used for the determination of tamsulosin in pharmaceutical capsule with no significant interferences of excipients.

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APA: Copy

AMANLOU, MASSOUD, GHAZI MOGHADAM, AMIN, BARAZANDEH TEHRANI, MALIHEH, & SOURI, EFFAT. (2014). VALIDATED SPECTROPHTOMETRIC METHOD FOR DETERMINATION OF TAMSULOSIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(1), 81-86. SID. https://sid.ir/paper/288350/en

Vancouver: Copy

AMANLOU MASSOUD, GHAZI MOGHADAM AMIN, BARAZANDEH TEHRANI MALIHEH, SOURI EFFAT. VALIDATED SPECTROPHTOMETRIC METHOD FOR DETERMINATION OF TAMSULOSIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(1):81-86. Available from: https://sid.ir/paper/288350/en

IEEE: Copy

MASSOUD AMANLOU, AMIN GHAZI MOGHADAM, MALIHEH BARAZANDEH TEHRANI, and EFFAT SOURI, “VALIDATED SPECTROPHTOMETRIC METHOD FOR DETERMINATION OF TAMSULOSIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 1, pp. 81–86, 2014, [Online]. Available: https://sid.ir/paper/288350/en

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