Hamartomas are benign lung tumors with an incidence of 0.025-0.32%. Endobronchial hamartoma is very rare. Only 1.4% of these tumors are endobronchial and the remaining are paranchymal. We report a 40-year-old man admitted for dyspnea and cough present for 8 years. He was a non-smoker and had been treated for asthma. Computed tomography of the lung showed a mass within the right main bronchus. Fiberoptic bronchoscopy showed translucent hyperaemic polypoid mass in the orifice of the right main bronchus. Microscopic examination of the specimen revealed chondroid hamartoma. Rigid bronchoscopy was performed for the patient and the lesion was removed by Nd: YAG laser. He recovered completely.

Mesenchymal hamartoma and hepatoblastoma are common causes of hepatic masses in pediatric population; they have similar radiologic and pathologic features. Herein, we present a case of mesenchymal hamartoma that was preoperatively diagnosed as hepatoblastoma. The mass was completely resected instead of being treated with preoperative chemotherapy. Postoperative pathological evaluation revealed mesenchymal hamartoma with free margins; the patient incidentally received the standard treatment. If we would have measured serum AFP in our patient, we could make the correct diagnosis preoperatively, because AFP increases largely in hepatoblastoma. When suspicious exists, serum AFP is a good guide in differentiating hepatoblastoma from mesenchymal hamartoma.

Dear Editor: Breast hamartoma is an uncommon, benign, slow growing lesion found in all age groups after puberty. This pathological entity has a reported incidence of 1.2% of benign lesions and 4-8% of benign breast tumors in women (1, 2). It appears that with the increasing use of breast screening more hamartomas are likely to be identified. This rare pathological entity consists of a well-circumscribed, benign tumor, composed of variable amounts of fat, fibrous and glandular tissue that may contain various benign changes such as fibrocystic changes. Breast hamartomas usually present as painless mobile breast lumps in middle-aged women. Up to 60% of these benign breast lesions are soft and non-palpable (2).

Introduction Nasal chondromesenchymal hamartoma is a benign tumor that was described in 1998. The occurrence of this lesion is especially rare, with only 21 cases reported in the international literature. It is a benign mass lesion of the nasal cavity predominantly described in young infants. To our knowledge, only one case in an older child has been reported, and no cases have been reported in adults. Case Report: A 52-year-old woman was presented with a one-year history of progressive left-sided nasal obstruction. She had no associated rhinosinusitis or atopic symptoms, and experienced no symptomatic relief with the use of topical nasal steroid spray. Nasal endoscopy revealed that a large polypoid mass was arising superior to the left inferior turbinate. Computed tomography demonstrated a 4.6´4.4-cm partially mineralized left nasal soft-tissue lesion. The mass abutted and displaced the vertical strut of the left middle turbinate laterally, contacted the septum medially, and extended superiorly to, but did not breech, the cribriform plate. Complete transnasal endoscopic excision was performed. Intraoperative examination revealed a mass that was distinct from the left inferior and middle turbinates, arising in slender stalk-like fashion from an intact nasal roof. Microscopic examination of the specimen revealed a polypoid lesion consisting of variably sized nodules that were predominantly composed of mature hyaline cartilage surrounded by a cellular mesenchymal stromal component which included cellular spindled areas as well as myxoid features.

Hamartomas are nontumoral lesions composed of disordered proliferation of normal and abnormal tissue components.Lung hamartomas are composed of irregular native tissues such as cartilage, fat, smoth muscle and tubules lined by bronchial or bronchiolar Epithelium.These are rare lesions often presenting as a small solitary mass in lung paranchyma of adults discovered radiologically as a coin lesion.They are acquired proliferations although some chromosomal aberrations are observed. This is a report of a lung Hamartoma and review of the recent related literature.

Background: Nasal chondromesenchymal hamartoma (NCMH) is a rare benign tumor almost always found in children. NCMH was first described by McDermott in 1998. To the best our knowledge, about 50 NCMH cases have been reported worldwide with very few adult cases and no long-term follow-ups. Case Presentation: Here, we report a 43-year-old woman who referred to the Otolaryngology Clinic of Payambar Azam Hospital, Bandar Abbas, Iran, in 2008, with a one-year history of progressive left-sided nasal obstruction that had not relieved with topical nasal decongestants and steroid sprays. A unilateral left-sided nasal soft-tissue mass was found upon examination. Histological and immunohistochemical analyses were consistent with NCMH. Trans-nasal endoscopic excision showed good results and no sign of recurrence has been observed after 12 years of regular follow-up. Conclusion: Awareness of imaging and immunohistochemical characteristics of NCMH combined with the probability of presentation in the adult population are necessary for correct diagnosis and adequate therapy.

Folliculosebaceous Cystic Hamartoma (FSCH) is a cutaneous hamartoma comprised of follicular, sebaceous and mesenchymal elements, and usually occurring during adulthood. Congenital and childhood presentations of this lesion are exceedingly rare. We describe herein a case of congenital FSCH on the midline and posterior region of the neck in a 1-year-old male infant and highlight the clinicopathological features of this rare lesion.