During the first phase (collection and identification) 250 species of Yazd province medicinal plants were identified. They classified in 181.genera and 65 families. Scientific, Persian, and local name of species, habitat, useful parts, chemical compounds, folklore of medicinal action of uses, preparation and consumption method and distribution were mentiened in this paper.Most of the medicinal plants were related to Labiatae with 24 species, Composite with 19 species and Cruciferae with 18 species, Rosaceae with 20 species, Umbelliferae and Liliaceae each with 12 species and Solanaceae and Malvaceae families each with 9 species, in Yazd province.In second phase (domestication) seeds and seedling were used from Natural Resources and Animal Affairs Center of Yazd Province, and Research Institute of Forests and Rangelans for cultivation. They were planted in spring and autumn. Planting date, phenology and compatibility of species with Yazd climatical conditions were studied. In addition to familiarity with propagation method, plant and diseases, water and fertilizer requirements were surveyed, as far as possible. The results show that 136 species out of 154 species completed their phenology stage, 72 species had compatible with research station of medicinal plants, 12 species did not germinat and 6 species died after germination.