Although tuberculosis of appendix is rare, but the prevalence in some areas, due to socioeconomic problems, in people who have unhealthy sanitary habits, is 0.1- 0.3%.We report a case of Granulomatose Appendicitis, who was operated on for acute Appendicitis, with no detectable disorders elsewhere in the body, in January 2004.She had been healthy and satisfied for seven months. But she was admitted to Toos Hospital in August 2004, after she was experiencing weight loss, anorexia, anemia, fatigue, ascites and constipation from the previous month. She was very ill and depressed. Examination of respiratory and cardiovascular systems was normal. Apart from a CA 125 which was 1800, and slight anemia, laboratory studies were normal. Report of abdominaland pelvis CT Scan showed cystadenocarcinoma of the ovary. Examination of ascites fluid, which was clear, showed inflammatory cells, and negative for malignancy.With provisional diagnosis of carcinoma, the patient was taken up for surgery. We aspirated 5000 ml of fluid, and found seeding all over the peritoneal cavity, but no pus or any tumoral lesions in the cavity. We took some biopsies which was sent for cytopatology. We performed a closed drainage with a Foley catheter No: 14 (closed drainage), and then closed the abdomen. Anti tuberculous treatment was started with four drugsin conventional doses. Post-operative course was uneventful, we removed the drain which was clamped, most of the times, on the 7th post-operative day. She was discharged on the 10th post-operative day, with very good recovery, no remarkable ascites or discharge. She has been satisfied, and symptom free so far (December 2005).