Introduction & Objective: Cardiac surgery in Iran has been associated with different facilities, equipment and patient populations in comparison to countries from which most of the academic papers used for identification of risk factors related to outcome and subsequent construction of risk stratification models originate from.Material & Methods: During 15 months all of patients admitted for adult cardiac surgery using cardiopulmonary bypass in a university affiliated teaching hospital were enrolled in a prospective study. Appropriate statistical tests were used to analyze data for mortality and morbidity.Results: There were 730 adults (63% male, 37% female), with an age range from 16 to 82 (mean 51.4 ± 14.4). A mortality rate of 5.3% and morbidity of 14.8% (major + minor) were observed in the whole group. Factors correlated with mortality were: age (p = 0.019), emergency surgery (p < 0.0001), redo cardiac surgery (p = 0.01), LV aneurysm (p < 0.001), presence of catastrophic states (p < 0.001), low ejection fraction (p = 0.04), history of hypertension (p = 0.05), the individual surgeon operating (p < 0.0001), and CPB duration (p < 0.0001). Factors affecting morbidity included: female gender (p = 0.04), age (p = 0.03), emergency surgery (p = 0.001), redo surgery (p = 0.008), and catastrophic states (p < 0.001). Conclusions: The mortality in our setting may be compared with reports presented in the literature. Age, emergency surgery, redo cardiac surgery, and catastrophic states are statistically related to both mortality and morbidity.