Objective The purpose of this study was to design a strategic management model for early prevention of addiction with a cultural approach. Method Using a sequential exploratory design (qualitative-quantitative), we evaluated the factors and finally developed a strategic management model for early prevention of addicton with a cultural approach. Thus, in the Delphi phase, a 46-member panel of experts from different areas of addiction prevention with a cultural approach selected by purposeful sampling was used to collect data through a questionnaire. In this phase, two methods of communication evaluation and focal group formation were used to validate the model, and two methods of repeatability and transferring capability (generalizability) were used for validation. In the SWOT phase, through a purposeful sampling method, a focal group consisting of 8 experts from the field of early prevention of addiction with a cultural approach was formed. Different stages of SWOT study were performed by Delphi questionnaire. Finally, by identifying the appropriate weights obtained from the evaluation of internal and external factors, the strategic action of strategic management of early prevention of addiction with a cultural approach was determined. In this phase, qualitative formal content validity was used for the validity of the instrument, and Cronbach's alpha test was used for the validity of the internal consistency of the items. Results The results of Delphi phase showed that a total of 38 variables included four factors including: (a) empowerment; (b) social services; c) Social participation, d) governance after four rounds were identified as the effective factors on the strategic management of the early prevention of addiction with the cultural approach and were agreed by the experts. Conclusion SWOT results showed that strategic management strategy of early prevention of addiction with cultural approach is competitive strategy (diversification). Hence, eight final strategies and models were formulated.