Coronary artery disease (CAD) is one of the most important diseases in the developing and industrialized countries. Major CAD risk factors are diabetes mellitus, hypertension, tobacco smoking and hyperlipidemia. Angiographic plaque morphology is correlated with the clinical status and prognosis of patients. In a cross sectional study, morphology of coronary artery lesions evaluated in patients with tobacco smoking and those with hyperlipidemia in coronary angiography. One hundred male patients were selected. Fifty of the patients had hyperlipidemia and the rest were smokers. The mean age of smoking patients was 45.3 years old with standard deviation of 3.7. The results were as follows: morphology of coronary artery lesions were 24.3% simple and 45.9% complex in smoking patients and 29.3% simple and 45.1% complex in hyperlipidemic Group The difference was not statistically significant, (X2=1.76). in conclusion, it seems both smoking and hyperlipidemic carry equal risk factors in the developing of vascular plague.