STUDY OF THE EFFECT OF MORUS ALBA LEAVES EXCTRACTS ON STREPTOZOCIN INDUCED DIABETES IN MICE

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ARZI A.; GHANAVATI J.; ZAHEDI S.

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Paper Information

Journal: Jundishapur Scientific Medical Journal Year:2001 | Volume:- | Issue:30 Page(s): 27-34

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Title

STUDY OF THE EFFECT OF MORUS ALBA LEAVES EXCTRACTS ON STREPTOZOCIN INDUCED DIABETES IN MICE

Author(s)

ARZI A. | GHANAVATI J. | ZAHEDI S. | Issue Writer Certificate

Keywords

MORUS ALBAQ3

DIABETESQ2

MICEQ4

STREPTOZOCINQ2

GLIBENCLAMIDEQ3

Abstract

In traditional medicine the Moruseae family is widely used in lowering the blood sugar. In this study the effect of Monls alba leaves extract on blood sugar in MICE was investigated. Extraction was carried out through maceration method and measurement of blood sugar level was made by orthotoluidine method. Statistical analysis was done by ANOVA and Newman Keuls test. Various doses of aqueous, alcoholic and hydro-alcoholic extracts of MORUS ALBA leaves (150, 200, 300 & 350 mglkg) were administrated orally. Results showed that the hydro-alcoholic extract with 250-mg/kg dose had the most significant effect in lowering the fasting blood sugar in MICE. In glucose tolerance test, the highest effect in lowering the blood sugar level, was observed 75 minutes after administration of hydro-alcoholic extract. In order to induce DIABETES in MICE, STREPTOZOCIN (100 mglkg) was injected interaperitonally. Hydro-alcoholic extract (250 mglkg) significantly decreased the blood sugar in diabetic MICE. Oral administration of GLIBENCLAMIDE (20 mglkg) did not decrease the blood sugar of diabetic MICE significantly. In order to study the toxic effect of Alorlls alba leaves extract after administering 1600 mglkg of the extract, within 72 hours, no fatal effects was observed in the animals.

Cites

THE STUDY OF ANTIOXIDANT POTENTIAL OF MORUS ALBA L. LEAVES EXTRACT

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APA: Copy

ARZI, A., GHANAVATI, J., & ZAHEDI, S.. (2001). STUDY OF THE EFFECT OF MORUS ALBA LEAVES EXCTRACTS ON STREPTOZOCIN INDUCED DIABETES IN MICE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, -(30), 27-34. SID. https://sid.ir/paper/12864/en

Vancouver: Copy

ARZI A., GHANAVATI J., ZAHEDI S.. STUDY OF THE EFFECT OF MORUS ALBA LEAVES EXCTRACTS ON STREPTOZOCIN INDUCED DIABETES IN MICE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2001;-(30):27-34. Available from: https://sid.ir/paper/12864/en

IEEE: Copy

A. ARZI, J. GHANAVATI, and S. ZAHEDI, “STUDY OF THE EFFECT OF MORUS ALBA LEAVES EXCTRACTS ON STREPTOZOCIN INDUCED DIABETES IN MICE,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. -, no. 30, pp. 27–34, 2001, [Online]. Available: https://sid.ir/paper/12864/en

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