Introduction: Propolis is a beehive product which contains antioxidants. It also has anti-bacterial, anti-viral, anti-fungal, anti-carcinogenic and anti-inflammatory properties. The aim of the present article was to review literature and collect data on various applications of propolis to promote oral health.Materials and Methods: Twenty-two different studies were selected, based on inclusion criteria, by running a search for the key word “propolis”, alone and/or combined with “oral health” and “dental treatment” in national and international electronic databases including medlib.ir, SID, Iranmedex, Magiran, PubMed and ISI Web of Knowledge from 1997 to 2009. The twenty-two selected articles were published from 1997 to 2009.Results: Efficacy of propolis in wound healing, as an intracanal irrigation agent, in caries prevention, in the treatment of periodontitis and dentinal hypersensitivity, and as an anti-fungal and anti-bacterial agent has been evaluated and demonstrated in different dental studies.Conclusion: Considering the useful characteristics of this material including anti-inflammatory activity, antibacterial and anti-fungal effects and particularly provoking the immune system, which might be useful in preventing many diseases, it seems that this material has the potential to be used in dental sciences; however, further evaluations are necessary.