Distressed textures are regions which are separated from life evolution cycle and became the bone of problems and inefficiencies. Nevertheless, these textures account for high percentage of urban population, and yet have numerous capacities and potentials for future intra-city developments. Dealing with distressed and inefficient urban textures is not apart from dealing with economic, cultural and social realities, and entails careful, comprehensive and realistic planning. In recent years, urban regeneration has been brought up as a new approach for improvement and renovation of these textures. “Urban regeneration” approach is beyond objectives, desires and achievements of “urban renovation”, “urban development”, and “urban improvement”, and has comprehensive, consistent and sustainable outlook by considering all social, economic, physical and environmental aspects. The current study has been carried out by understanding effective factors on urban distressed textures and evaluating the sustainability and unsustainability of District 10, and using SWOT-QSPM methods; research variables were determined through documentary and library studies that include social, economic, and environmental indicators . Throughout the survey method, the required information was collected and analyzed using the entropy criterion and SWOT-QSPM model. Further quantitative results showed that this area is economically unstable in the first place due to its social and environmental dimensions. The instability of the economic dimensions of the tissue is that: this leads to the instability of the other dimensions of the texture and ultimately shows itself as a physical instability. Thus, the later approach of sustainable urban regeneration with the strategy (economic regeneration and community-based recreation), due to its integrated globalization and interactivity, can be an optimal version to intervene with this tissue.