Aim: The purpose of this study was testing cross-gender generability of the model of structural relationships between personality traits, coping styles, perceived academic stress and reactions to stressors with scales of subjective well-being.Methods: In the correlational study, from total of 5000 students, from regions of 5 and 12 of Tehran, 400 students (160 males and 240 females), who were selected by multistage random sampling method, completed the Big Five Inventory BFI, John, Donahue & Kentle (1991), the Coping Inventory for Stressful Situations-Short Form, Cohan, Jang &Stien (2006), Student-Life Stress Inventory, Gadzella & Baloglu (2001), and Scales of Subjective Well-being of Keyes, Shmotkin & Ryff (2002).Results: The results of the moderating effects of sex groups by multiple regression models showed that relationship between personality traits, coping styles, perceived academic stress and reactions to stressors with subjective well-being was similar for the two sex samples.Conclusion: In sum, these results show that functional properties of the multiple psychological constructs for predicting emotional and cognitive components of subjective well-being were similar for the two sex samples. Therefore, to enhance subjective well-being among male and female university students, similarity in content of intervention programs is suggested.