This research wish answer this question: what is social, political, economical, and cultural background caused evaluation of Iranian urban spaces from Ilkhanid until Safavid and formation of Isfahan Urbanism School? Method of this research is interpretational-historical method and based on librarian data. For the answer question of research, cities of Iran that have urbanism works in this era are selected. These cities include Tabriz, Soltanie, Samarkand, Herat, Mashhad, Neyshabur, Yazd, Kerman, Qazvin, Shiraz, and Isfahan. Then urbanism evaluations, alterations and changes of these cities are survey and compare by social, cultural, political and economical evaluations from Ilkhanid until Safavid era. These evaluations from Ilkhanid era prepared appearance urban evaluations; completion old urban spaces and formation of new town besides old city and new urban spaces and elements (include governmental square, boulevard, garden-palace complex, Sufism religious complex). Establishment of Safavid Empire, especially shah Abbas's works prepared Isfahan Urbanism School. Therefore urban elements that formed in previous era completed and then prepared to combine them and to form Isfahan Urban School in Safavid era. Too, commercial complex or religious complex (related to canonical Shiism) in Isfahan School was becomes the core of city in lieu of Sufism religious complex in pervious era.