The main objective of this research is to investigate the influential factors of individual, social, cultural, family, biomedical, environmental and rural change during the last three decades on the villagers' tendency towards drug abuse and addictive behavior. This research is a descriptive-analytic study using a survey method and researcher-made questionnaire. Anomie theories of Merton and Durkheim, the anomy theory of Sutherland, the subculture theory of Albert Cohen, the Parsens social action theory, the theory of social control, the theory of Alexander's compatibility, and the theory of Malvin Seeman on alienation, are used as the theoretical framework of the research. The main hypothesis of the research is that there is a significant relationship between the above factors (as independent variables) and the tendency toward drug abuse (as a dependent variable). The statistical population of the present study is the adult population (18 years and older) living in rural areas of Ashkhurat (Lower, Oliya, Shwaileh). According to the size of the statistical population, 109 villages were selected as sample size, taking into account the size of the household and the gender. The sample size was 361 based on Cochran formula and 381 questionnaires were analyzed after the return. For analyzing the data, two methods of descriptive and inferential statistics and SPSS software and multiple regression models have been used to test the research hypotheses. The results of this study indicate that the best predictor, of rural abuse are environmental, cultural, socio-economical, social, biological and medical, individual drug, familial Factors.