The aim of this study was to investigate the effects of different rates and periods of sewage sludge and sewage sludge enrichment with chemical fertilizer application on some chemical characteristic and enzyme activity of soil in 2008. This experiment was carried out in a randomized complete block design with three replications. Themain factors was fertilizer treatments (T1=no organic and inorganic fertilizer, T2=chemical fertilizer (potassium sulfate, tripill super phosphate and urea 150, 150 and 200 Kg. ha-1 respectively), T3 and T5 20 and 40 Mg. ha-1 respectively, T4 and T6, 20 and 40 Mg. ha-1 with half T2 respectively) and the secondary factor three consecutive times of sewage sludge application (2006, 2006+2007, 2006-2008 years). Soil samples were collected from 0-20 cm depth at end of 60th day of application. Results indicated that with increasing application periods of sewage sludge the amount of soil organic matter enhanced, significantly. An increasing trend was observed in total nitrogen (TN). While mean, with increasing the rates and application periods, the amount of available K and P increased significantly. Activities of urease and alkaline phosphates improved with increasing the organic fertilizers and application periods. Maximum amount of available K, P and total N, activities of urease and alkaline phosphates were observed in 40 sewage sludge ha-1+1.2 chemical fertilizer treatment. Significant correlation was observed among enzyme activity, organic soil matter, TN, K and P. Therefore application of sewage sludge, by increasing the amount of O.C, TN, available P and K, caused to enhance the enzyme activity in soil.