One of the key concepts that rapidly opened its way and design in the literature of international relations literature in the late 1990s is the concept of soft power. It is considered as the important characteristics of the third millennium in the international arena and has gained influence in countries using the tools of soft power because of its low cost and legitimacy in comparison with hard power. From this perspective, as far as the concept is concerned, soft power has the ability to shape the preferences of others through persuasion, absorption and coercion in a subtle way to be used to obtain the desired results. United States of America has always been aware of this issue over three decades after the Islamic Revolution, and because of its anti-hegemonic nature, it has tried to put pressure on the Islamic Republic of Iran in order to pave the way for change in the approach taken by Iran’ s brokers. Hence, this paper attempts to answer the question: what are the new scenarios in the context of United States of America, according to the neoliberalism approach of its soft power against the Islamic Republic of Iran? Accordingly, the subject of this study is to understand the concept of soft power, new ways and scenarios soft power United States of America including psychological warfare-the media, economic sanctions, human rights, cyber war, Iranophobia and put pressure on Iran (and Disarmament) Iran's strategic ally in the Middle East against the Islamic Republic of Iran, in an attempt to investigate the strategies of Iran towards.