The metal industries generally create the contaminants in their lines of production and mostly enter them directly to the environment (Selinus et al., 2005). The region of Dandy and Maahneshan in Zanjan province is one of the regions having various metal industries in lead and zinc is facing the problem as the risk of toxic metal pollution. The studies show that the rate of many elements such as lead, zinc, cadmium and arsenic, are higher than allowed limit in comparison with international standards such as EPA-WHO; and these anomalies are directly connected with the leach cakes abandoned around the factories of the region and also with the move of dust resulted of dry wastes and the industrial chimneys. The incompliance of the rate of the elements presented in eater and soil of the region with the international standards brings this question in mind that which types of effects would have this environmental abnormality on the physiology of animals and plants of the region. The rate of heavy elements in the blood of animals represents that their blood are contaminated with these elements too and the most amounts of this contamination is related to cadmium and arsenic. In some cases, the rate of these elements reaches up to 10 times more than in the clean areas. This means a hazard that can put the health of cattle of region in difficulties. In order to prove this matter and as an evidence, some samples of cattle wool and hair were obtained and all of them confirmed the rate of contamination of lead, arsenic and cadmium in the body of the animals. Lead and cadmium level which is 4-8 times more than allowed limit were seen in wool of sheep more that the caws, but the rate of arsenic was more in the caws hairs. The measured plant samples also showed similar effects, and because the studied plants and the cattle both are of the human nutritional needs, it should be thought to solve this problem. Alongside these issues, it is considered the psychological aspect and the change of living system of the habitants. The realized research expressing the rate of anomalies and the amount of lead, cadmium and arsenic in blood, hair and food plants of the study region shows that the metal industries, especially of the lead and zinc, have left harmful effects on cattle and plants of the region.