Cash reserves are important part of firms' assets. In previous studies many variables including of financial distress, growth opportunities, firm size, debt contract terms, banking relationships, investment opportunity cost, financial leverage, assets’ liquidity the capacity to generate cash flows, percentage of dividend payout, the ratio of capital expenditures in the fixed assets to net fixed assets at the beginning of period (INV), firm age, business group membership and accruals quality are introduced as determinants of cash holdings. The main goal of this paper is to review the relationship between above factors as independent variables and cash holdings as dependent variable in Tehran Stock Exchange. Therefore, 129 firms that their required data for a ten year period (1379-1387) was available are studied. The multivariate pooled regression model is used to test the hypotheses. The findings indicate that independent variables that are used in research model explain 86 percent of variation in cash holdings in Tehran Stock Exchange.