Background: Improving the self-effi cacy of cardiac patients is one of the pressing necessities that must be considered in the healthcare system. Meeting this urgent need requires comprehensive educational programs. Objectives: Therefore, the present study aimed at exploring the impact of empowerment on the self-effi cacy of patients with ischemic heart disease who had been hospitalized in Imam Khomeini Hospital affi liated to Lorestan University of Medical Sciences. Methods: This clinical trial was carried out in 2018 on patients with ischemic heart disease who had referred to Imam Khomeini Hospital in Pol-e Dokhtar, Lorestan province, Iran. A total of 56 patients were randomly chosen and assigned to the control and experimental groups. The standard chronic disease self-effi cacy scale (CDSES) was used for data collection. The empowerment program was presented in three 45-minute sessions, and the data were analyzed by SPSS version 23 using covariance, independent t test, and descriptive statistical tests. Results: The results of the independent t test revealed no signifi cant diff erence in the mean scores of self-effi cacy between the two groups before the intervention. However, after the intervention and at the fi rst and second phases of control, the mean score of selfeffi cacy was higher in the experimental group than in the control group. Moreover, the results of covariance analysis established that while self-effi cacy promoted in the experimental group, it did not change in the control group. Conclusions: Empowerment training can promote self-effi cacy in patients with ischemic heart disease, which, in turn, can facilitate their treatment process and ultimately enhance the health system effi cacy.