The research is being experimental and an empirical attempt to measure. The effects of the two approaches of treatment by drugs (Clomipramine) and psychotherapy (Cognitive Behavior Therapy) each separately and along with each other. We intended to measure the therapeutic results of each of the Cognitive Behavior Therapy and Clomipramine separately, and both together, on a group of patients - 8 to 17 ages - affected with Obsessive Compulsive Disorder. The present research has showed that, Clomipramine and Cognitive behavior therapy will be effective in the treatment of obsessive-compulsive disorder, but cognitive behavior therapy is more effective than Clomipramine, and it is more stable than Clomipramine in the treatment of obsessive-compulsive disorder among children and adolescents.