This experiment was carried out in randomized complete block design to study the effect of ionophore anticoccidial drugs (Salinomycin, Semduramicin and the combination ratio) and compare their effects on the behavior of the broiler chicks. In this experiment, we considered 272 one-day-old commercial broiler chicks from the Ross 308. These chicks were divided into 4 groups and each group included 4 subgroups containing 17 chicks per sub-group. The groups were: 1) Basal diet, 2) Basal diet + 25 mg/kg Semduramicin, 3) Basal diet + 60 mg/kg Salinomycin, 4) Basal diet + 12.5 mg/kg Salinomycin + 30 mg/kg Semduramicin. The features studied were weight gain, feed intake, feed conversion, calcium, sodium and potassium concentration and also carcass characteristics. The results showed that, the group receiving combined drugs, reduced the body weight at the entire period of raising and the ages of 42 and 57 days-old (p<0.05), while there was not any significant difference of weight gaining in those groups that received Salinomycin and Semduramicin (T2 and T3). The feed intake was reduced, at the age of 42-day-old in group received combined drugs (T4) (p<0.05), while there was not any significant difference in the experimental groups, considering the feed intake at the ages of 21 and 56 days-old, and during entire raising period. Feed conversion was significantly reduced in the group receiving semduramicin (T2) (p<0.05). The results showed that there was a significant effect of the kind of drug being used, on the percentage of abdominal fat and the amount of calcium in blood serum (p<0.05). These two features in the group receiving Semduramicin, were higher in relation to the other group. The mutual effect among the experimental groups on the features of weight gain, feed conversion, feed intake and also the percentage of abdominal fat and the concentration of calcium in blood serum, were significant (p<0.05).