The purpose of this study was to investigate the associations of personality characteristics with intimate relationships in spouses of drug dependents men who conferred to addiction disuse centers in Ahwaz. The sample consisted of 200 spouses of drug dependents men which were selected randomly via simple sampling method. To collect data NEO Personality Five–Factor Inventory and Intimacy Scale were implied. The research was a descriptive study. to analysis the data, simple correlation and regression analysis procedures were applied. The results indicated that the neuroticism had significant negative correlation with intimate relationships while extraversion, openness, agreeableness and conscientiousness had significant positive correlation with intimate relationships. Finally, a multiple regression analysis showed that neuroticism, extraversion, openness, agreeableness, conscientiousness had multiple significant correlations with intimate relationships. The results also revealed that neuroticism, conscientiousness, openness and extraversion were stronger predictors to intimate relationships.