Background & Aims: Being discharged on the contrary to the medical advice from the hospital cancause the premature discontinuation of treatment by patients or their family, and sometimes it results inthe re-hospitalization or death of patients. It can be a detector of serious problem and patientdissatisfaction. This study aimed to assess the rate and causes of discharge against medical advice ininpatient and outpatient wards of Shahid Madani hospital in khoy.Materials & Method: This cross-sectional study was performed in Shahid Madani hospital in khoy cityin 2014. All of inpatient and outpatient (1663 patients) that discharged the hospital against medicaladvice during the study period were included in the study. Data collection tool was a check list. Datawere analyzed by using descriptive and inferential statistics in SPSS 18.Results: The patients, who were discharged from the hospital against medical advice, were 6.82% of allinpatients and 19.65% of all outpatients in emergency ward. The most important reason for discharging(47.8%) was prolongation of hospital stay. Other reasons were listed as feeling better, tending to stay inthe hospital medical center, denial of treatment, dissatisfaction with the doctor, lack of facilities, dissatisfaction with the service provider and end stage of the patient.Conclusion: As far as being discharged against medical advice can disrupt the patient's treatment, so itis advised to prevent it by increasing the patients awareness to the possible effects of illness, planning abetter treatment protocol for patients, stabilizing the clinical social workers to identify and assessing thepatient’s problems, creating a better space to relax patients and their relatives, and by creating a pleasantenvironment.