Mystical tourism as a social and cultural reality has positive tasks and functions in society. Knowledge tourism is a branch of cultural tourism that has a direct relationship with mysticism so that the tourist set up a targeted journey to gain knowledge or to visit holy mystical places. Psychological recovery, peace of spirit, enjoying spiritual atmosphere, observing different manifestation of customs, spiritual products, inclinations (mystical-spiritual), deserting life, grace, sustainable peace, resources and benefit discovery, economic and commercial evolution, acquiring abundant income, job creation, understanding spiritual culture, retrieving national pride, cultural behavior (Islamic-Iranian), commemoration of cultural legacy, understanding life styles, preserving cultural resources, emerging cultural exchanges, mutual connection and exchange (host and guest), balance, interaction, reformation, urban development, etc. are among the most important functions and positive works in this field in society. This research tries to extract an array of effective factors over the expansion and growth of mystical tourism industry in Zanjan Province. Therefore, by offering solutions and proposals in terms of entrepreneurship ecosystem and creating correct planning based on realities and need (host and guest), removing lack of facilities and services, increasing trust and social capital among local community and tourists, stability, precise control and supervision in the field of economy, welfare services, hygiene, etc., one can help a great deal to development solutions and removing the barriers of development in this field in Zanjan Province.