To study the effects of irrigation treatments on yield, water use efficiency (WUE), and quality characteristics of bread wheat, an experiment was conducted based on randomized complete blocks as a split plot design with 4 replicates, at the experimental farm of Agricultural and Natural Resources Research Center of Yazd, during 2006-2007. The main plots were allocated to four irrigation frequencies (8, 10, 12 and 14 days) and the sub plots were planted to four bread wheat cultivars (Backcross Roshan, Sistan, WS-9 and Pishtaz). The results indicated that the irrigation intervals and cultivars had significant effect (P<0.01) on grain yield, WUE, grain protein, and grain wet gluten. Also, interaction between treatments had significant effects on grain yield, WUE and grain wet gluten (P<0.01), but not on grain protein. The highest average grain yield and WUE were produced in 8-day irrigation interval (and were, respectively, 3258 kg/ha and 0/.65 kg/m3), However, 14-day irrigation frequency had the highest grain protein content at at 17/.28% followed by WS-9 cultivar (16/.67%). The latter cultivar contained the highest grain wet gluten equal to 53/.08%. Under 8-day irrigation treatment, Sistan cultivar produced the maximum grain yield (3875 kg/ha) and WUE (0/.77 kg/m3). The greatest percent of grain protein belonged to WS-9 cultivar under 14-day irrigation frequency (17/.79 %), while Sistan cultivar under the same irrigation had the maximum percent of grain wet gluten (55.42 %). The results of the experiment indicated that 8-day and 14-day irrigation intervals were favourable irrigation frequencies for production of the maximum grain yield and quality, respectively. Finally, based on the results, various varieties are suggested and for different production aims or irrigation management.