Background and Aim: Chronic kidney failure is a progressive and irreversible disorder that impedes the ability of the kidney to dispose waste. Hemodialysis, diet, and fluid restriction are necessary to provide long-term health for patients and ensure their survival. This study aimed to determine the role of face-to-face education on body weight and some serum parameters in hemodialysis patients of Shahid Mohamadi Hospital in Bandar Abbas, 2011. Materials and Methods: In this clinical trial study, samples were selected through convenience sampling. Fifty-two patients were selected randomly for the intervention group, and 52 for the control group. The two groups were matched in terms of gender, weight, marital and employment status, education, duration of treatment with hemodialysis, and drugs taken. Following dialysis, the patients in the intervention group received three 20-minute-long training sessions. Serum indices such as hematocrit, blood urea nitrogen, creatinine, sodium, potassium, and phosphorus levels as well as weight gain between two sessions of dialysis were measured before and after training; the obtained data were analyzed using SPSS (version 13), descriptive statistics, paired t-test, independent t-test, Wilcoxon, ANOVA, chi-square, Pearson correlation and fisher exact test.Results: Results showed that the average weight gain, hematocrit, blood urea nitrogen, creatinine, sodium, potassium and phosphorus levels in the periods before and after the training program had significant differences in the intervention group. Also, the differences between changes in these indicators before and after the training between the two groups were significant (P<0.001). The serum calcium levels were not of significant difference in both groups before and after the program (P>0.05).Conclusion: This study found the favorable effects of education on reducing indicators such as serum sodium, potassium, phosphorus, blood urea nitrogen and creatinine, increasing hematocrit, and maintaining fluid restriction. This can protect hemodialysis patients against the complications of kidney disease. It is recommended that more serious training be done by nurses for this group of patients.